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A fully integrated new paradigm for lithium?s mode of action ? lithium utilizes latent cellular fail-safe mechanisms #MMPMID28203080
van Woerkom AE
Neuropsychiatr Dis Treat 2017[]; 13 (ä): 275-302 PMID28203080show ga
It is proposed that lithium?s therapeutic effects occur indirectly by augmenting a cascade of protective ?fail-safe? pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg++] level.