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10.1001/jamaneurol.2016.1948 http://scihub22266oqcxt.onion/10.1001/jamaneurol.2016.1948 C5319642!5319642!27400367     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27400367&cmd=llinks): Failed to open stream: HTTP request failed! 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Association between Traumatic Brain Injury and Late Life Neurodegenerative Conditions and Neuropathological Findings |pdf=|usr=}}{{27400367}} gab.com Text Association between Traumatic Brain Injury and Late Life Neurodegenerative Conditions and Neuropathological Findings JO: JAMA Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27400367 #FOAvip IMPORTANCE: There is great interest in the late effects of traumatic brain injury (TBI). OBJECTIVE: To determine whether TBI with loss of consciousness (LOC) is associated with increased risk for clinical and neuropathological findings of Alzheimer?s disease, Parkinson?s disease, and other dementias. Our primary hypothesis was that TBI with LOC would be associated with increased risk for Alzheimer?s disease and neurofibrillary tangles. DESIGN: Prospective cohort studies which follow all participants (Religious Orders Study and the Memory and Aging Project, ROS and MAP) or all consenting participants (Adult Changes in Thought, ACT) to autopsy. Studies performed annual (ROS and MAP) or biennial (ACT) cognitive and clinical testing to identify incident cases of dementia and Alzheimer?s disease. SETTING: Members of a Seattle-area healthcare delivery system (ACT); priests and nuns living in orders across the US (ROS), and Chicago-area adults in retirement communities (MAP). PARTICIPANTS: 7,130 older adults; 1,589 came to autopsy. EXPOSURE: Self reported TBI reported when free of dementia, categorized as <1 hour vs. > 1 hour of LOC. MAIN OUTCOMES AND MEASURES: Clinical: incident all-cause dementia, Alzheimer?s disease, and Parkinson?s disease (all studies), and incident mild cognitive impairment and progression of parkinsonian signs (ROS and MAP). Neuropathology: neurofibrillary tangles, neuritic plaques, microinfarcts, cystic infarcts, Lewy bodies, and hippocampal sclerosis (all studies). RESULTS: 865 participants reported a history of TBI with LOC. In >45,000 person-years of follow-up, there were 1,537 incident dementia and 117 incident Parkinson?s disease cases. There was no association between TBI with LOC and incident dementia or Alzheimer?s disease. There were associations between TBI with LOC and incident Parkinson?s disease and progression of parkinsonian signs. There was no association between TBI with LOC and neurofibrillary tangles or neuritic plaques. There was an association between TBI with LOC and Lewy bodies, and with microinfarcts, though numbers of people with these findings were small. CONCLUSIONS AND RELEVANCE: Pooled clinical and neuropathology data from three prospective cohort studies indicate that TBI with LOC is associated with risk of Lewy body accumulation, progression of parkinsonism, and Parkinson?s disease, but not dementia, Alzheimer?s disease, neuritic plaques, or neurofibrillary tangles. Twit Text FOAVip Association between Traumatic Brain Injury and Late Life Neurodegenerative Conditions and Neuropathological Findings ????JAMA Neurol http://www.kidney.de/pget.php?&tw=1&pmid=27400367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27400367 #FOAvip English Wikipedia <ref>{{Cite pmid|27400367}}</ref> Association between Traumatic Brain Injury and Late Life Neurodegenerative Conditions and Neuropathological Findings #MMPMID27400367 Crane PK; Gibbons LE; Dams-O?Connor K; Trittschuh E; Leverenz JB; Keene CD; Sonnen J; Montine TJ; Bennett DA; Leurgans S; Schneider JA; Larson EB JAMA Neurol 2016[Sep]; 73 (9): 1062-9 PMID27400367show ga IMPORTANCE: There is great interest in the late effects of traumatic brain injury (TBI). OBJECTIVE: To determine whether TBI with loss of consciousness (LOC) is associated with increased risk for clinical and neuropathological findings of Alzheimer?s disease, Parkinson?s disease, and other dementias. Our primary hypothesis was that TBI with LOC would be associated with increased risk for Alzheimer?s disease and neurofibrillary tangles. DESIGN: Prospective cohort studies which follow all participants (Religious Orders Study and the Memory and Aging Project, ROS and MAP) or all consenting participants (Adult Changes in Thought, ACT) to autopsy. Studies performed annual (ROS and MAP) or biennial (ACT) cognitive and clinical testing to identify incident cases of dementia and Alzheimer?s disease. SETTING: Members of a Seattle-area healthcare delivery system (ACT); priests and nuns living in orders across the US (ROS), and Chicago-area adults in retirement communities (MAP). PARTICIPANTS: 7,130 older adults; 1,589 came to autopsy. EXPOSURE: Self reported TBI reported when free of dementia, categorized as <1 hour vs. > 1 hour of LOC. MAIN OUTCOMES AND MEASURES: Clinical: incident all-cause dementia, Alzheimer?s disease, and Parkinson?s disease (all studies), and incident mild cognitive impairment and progression of parkinsonian signs (ROS and MAP). Neuropathology: neurofibrillary tangles, neuritic plaques, microinfarcts, cystic infarcts, Lewy bodies, and hippocampal sclerosis (all studies). RESULTS: 865 participants reported a history of TBI with LOC. In >45,000 person-years of follow-up, there were 1,537 incident dementia and 117 incident Parkinson?s disease cases. There was no association between TBI with LOC and incident dementia or Alzheimer?s disease. There were associations between TBI with LOC and incident Parkinson?s disease and progression of parkinsonian signs. There was no association between TBI with LOC and neurofibrillary tangles or neuritic plaques. There was an association between TBI with LOC and Lewy bodies, and with microinfarcts, though numbers of people with these findings were small. CONCLUSIONS AND RELEVANCE: Pooled clinical and neuropathology data from three prospective cohort studies indicate that TBI with LOC is associated with risk of Lewy body accumulation, progression of parkinsonism, and Parkinson?s disease, but not dementia, Alzheimer?s disease, neuritic plaques, or neurofibrillary tangles. äAssociation between Traumatic Brain Injury and Late Life Neurodegenera(epmc).pdf DeepDyve Pubget Overpricing