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10.1099/mgen.0.000036 http://scihub22266oqcxt.onion/10.1099/mgen.0.000036 C5320625!5320625!28348819     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28348819&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28348819.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microb+Genom 2015 ; 1 (4): ä Nephropedia Template TP {{tp|p=28348819|t=2015. Recombination-mediated remodelling of host?pathogen interactions during Staphylococcus aureus niche adaptation |pdf=|usr=}}{{28348819}} gab.com Text Recombination-mediated remodelling of host pathogen interactions during Staphylococcus aureus niche adaptation JO: Microb Genom http://www.kidney.de/pget.php?&tw=1&pmid=28348819 #FOAvip Large-scale recombination events have led to the emergence of epidemic clones of several major bacterial pathogens. However, the functional impact of the recombination on clonal success is not understood. Here, we identified a novel widespread hybrid clone (ST71) of livestock-associated Staphylococcus aureus that evolved from an ancestor belonging to the major bovine lineage CC97, through multiple large-scale recombination events with other S. aureus lineages occupying the same ruminant niche. The recombination events, affecting a 329?kb region of the chromosome spanning the origin of replication, resulted in allele replacement and loss or gain of an array of genes influencing host?pathogen interactions. Of note, molecular functional analyses revealed that the ST71 hybrid clone has acquired multiple novel pathogenic traits associated with acquired and innate immune evasion and bovine extracellular matrix adherence. These findings provide a paradigm for the impact of large-scale recombination events on the rapid evolution of bacterial pathogens within defined ecological niches. Twit Text FOAVip Recombination-mediated remodelling of host pathogen interactions during Staphylococcus aureus niche adaptation ????Microb Genom http://www.kidney.de/pget.php?&tw=1&pmid=28348819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28348819 #FOAvip English Wikipedia <ref>{{Cite pmid|28348819}}</ref> Recombination-mediated remodelling of host?pathogen interactions during Staphylococcus aureus niche adaptation #MMPMID28348819 Spoor LE; Richardson E; Richards AC; Wilson GJ; Mendonca C; Gupta RK; McAdam PR; Nutbeam-Tuffs S; Black NS; O'Gara JP; Lee CY; Corander J; Ross Fitzgerald J Microb Genom 2015[Oct]; 1 (4): ä PMID28348819show ga Large-scale recombination events have led to the emergence of epidemic clones of several major bacterial pathogens. However, the functional impact of the recombination on clonal success is not understood. Here, we identified a novel widespread hybrid clone (ST71) of livestock-associated Staphylococcus aureus that evolved from an ancestor belonging to the major bovine lineage CC97, through multiple large-scale recombination events with other S. aureus lineages occupying the same ruminant niche. The recombination events, affecting a 329?kb region of the chromosome spanning the origin of replication, resulted in allele replacement and loss or gain of an array of genes influencing host?pathogen interactions. Of note, molecular functional analyses revealed that the ST71 hybrid clone has acquired multiple novel pathogenic traits associated with acquired and innate immune evasion and bovine extracellular matrix adherence. These findings provide a paradigm for the impact of large-scale recombination events on the rapid evolution of bacterial pathogens within defined ecological niches. äRecombination-mediated remodelling of host?pathogen interactions durin(epmc).pdf DeepDyve Pubget Overpricing