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10.1002/lary.26115

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suck abstract from ncbi


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pmid27726156      Laryngoscope 2017 ; 127 (3): 709-14
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  • Otoconia and Otolithic Membrane Fragments Within the Posterior Semicircular Canal in BPPV #MMPMID27726156
  • Kao WTK; Parnes LS; Chole RA
  • Laryngoscope 2017[Mar]; 127 (3): 709-14 PMID27726156show ga
  • Objective: Benign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder with an incidence between 10.7 and 17.3 per 100,000 persons per year. The mechanism for BPPV has been postulated to involve displaced otoconia resulting in canalithiasis. While particulate matter has been observed in the endolymph of affected patients undergoing posterior canal occlusion surgery, an otoconial origin for the disease is still questioned. Study Design: In this study, particulate matter was extracted from the posterior semicircular canal of two patients and examined with the scanning electron microscopy. Methods: The samples were obtained from two patients intraoperatively during posterior semicircular canal occlusion. The particles were fixed, stored in ethanol and chemically dehydrated. The samples were and sputter coated and viewed under a scanning electron microscope. Digital images were obtained. Results: Intact and degenerating otoconia with and without linking filaments were found attached to amorphous particulate matter. Many otoconia appeared to be partially embedded in a gel matrix, presumably that which encases and anchors the otoconia within the otolith membrane, while others stood alone with no attached filaments and matrix. The otoconia measured roughly 2 to 8 ?m in length and displayed a uniform outer shape with a cylindrical bulbous body and a 3+3 rhombohedral plane at each end. Conclusion: These findings suggest that the source of the particulate matter in the semicircular canals of patients with BPPV is broken off fragments of the utricular otolithic membrane with attached and detached otoconia. Level of Evidence: NA
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