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10.1016/j.freeradbiomed.2017.01.003 http://scihub22266oqcxt.onion/10.1016/j.freeradbiomed.2017.01.003 C5329068!5329068!28063941     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28063941&cmd=llinks): Failed to open stream: HTTP request failed! 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Nitro-oleic acid regulates growth factor-induced differentiation of bone marrow-derived macrophages |pdf=|usr=}}{{28063941}} gab.com Text Nitro-oleic acid regulates growth factor-induced differentiation of bone marrow-derived macrophages JO: Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28063941 #FOAvip Many diseases accompanied by chronic inflammation are connected with dysregulated activation of macrophage subpopulations. Recently, we reported that nitro-fatty acids (NO2-FAs), products of metabolic and inflammatory reactions of nitric oxide and nitrite, modulate macrophage and other immune cell functions. Bone marrow cell suspensions were isolated from mice and supplemented with macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with NO2-OA for different times. RAW 264.7 macrophages were used for short-term (1?5 min) experiments. We discovered that NO2-OA reduces cell numbers, cell colony formation, and proliferation of macrophages differentiated with colony-stimulating factors (CSFs), all in the absence of toxicity. In a case of GM-CSF-induced bone marrow-derived macrophages (BMMs), NO2-OA acts via downregulation of signal transducer and activator of transcription 5 (STAT5) and extracellular signal-regulated kinase (ERK) activation. In the case of M-CSF-induced BMMs, NO2-OA decreases activation of M-CSFR and activation of related PI3K and ERK. Additionally, NO2-OA also attenuates activation of BMMs. In aggregate, we demonstrate that NO2-OA regulates the process of macrophage differentiation and that NO2-FAs represent a promising therapeutic tool in the treatment of inflammatory pathologies linked with increased accumulation of macrophages in inflamed tissues. Twit Text FOAVip Nitro-oleic acid regulates growth factor-induced differentiation of bone marrow-derived macrophages ????Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28063941 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28063941 #FOAvip English Wikipedia <ref>{{Cite pmid|28063941}}</ref> Nitro-oleic acid regulates growth factor-induced differentiation of bone marrow-derived macrophages #MMPMID28063941 Verescakova H; Ambrozova G; Kubala L; Perecko T; Koudelka A; Vasicek O; Rudolph TK; Klinke A; Woodcock SR; Freeman BA; Pekarova M Free Radic Biol Med 2017[Mar]; 104 (ä): 10-9 PMID28063941show ga Many diseases accompanied by chronic inflammation are connected with dysregulated activation of macrophage subpopulations. Recently, we reported that nitro-fatty acids (NO2-FAs), products of metabolic and inflammatory reactions of nitric oxide and nitrite, modulate macrophage and other immune cell functions. Bone marrow cell suspensions were isolated from mice and supplemented with macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with NO2-OA for different times. RAW 264.7 macrophages were used for short-term (1?5 min) experiments. We discovered that NO2-OA reduces cell numbers, cell colony formation, and proliferation of macrophages differentiated with colony-stimulating factors (CSFs), all in the absence of toxicity. In a case of GM-CSF-induced bone marrow-derived macrophages (BMMs), NO2-OA acts via downregulation of signal transducer and activator of transcription 5 (STAT5) and extracellular signal-regulated kinase (ERK) activation. In the case of M-CSF-induced BMMs, NO2-OA decreases activation of M-CSFR and activation of related PI3K and ERK. Additionally, NO2-OA also attenuates activation of BMMs. In aggregate, we demonstrate that NO2-OA regulates the process of macrophage differentiation and that NO2-FAs represent a promising therapeutic tool in the treatment of inflammatory pathologies linked with increased accumulation of macrophages in inflamed tissues. äNitro-oleic acid regulates growth factor-induced differentiation of bo(epmc).pdf DeepDyve Pubget Overpricing