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10.1073/pnas.1615771114 http://scihub22266oqcxt.onion/10.1073/pnas.1615771114 C5338555!5338555!28193861     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28193861&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28193861.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (9): E1698-706 Nephropedia Template TP {{tp|p=28193861|t=2017. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems |pdf=|usr=}}{{28193861}} gab.com Text Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28193861 #FOAvip To combat infections with bacterial pathogens that reside and replicate inside specialized intracellular vacuoles, the innate immune system must be able to distinguish these pathogen-containing vacuoles (PVs) from endogenous vesicles. Here, we demonstrate that the host can detect the presence of bacterial secretion systems as hallmarks of PVs. The insertion of bacterial protein secretion pores destabilizes vesicular membranes, allowing host carbohydrate-binding proteins to access the sugar-decorated luminal side of vacuolar membranes. We show that a specific carbohydrate-binding protein recruits members of a family of antimicrobial GTPases to PVs. Our findings reveal how host cells deliver antimicrobial defenses specifically to intracellular vesicles occupied by pathogens. Twit Text FOAVip Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28193861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28193861 #FOAvip English Wikipedia <ref>{{Cite pmid|28193861}}</ref> Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems #MMPMID28193861 Feeley EM; Pilla-Moffett DM; Zwack EE; Piro AS; Finethy R; Kolb JP; Martinez J; Brodsky IE; Coers J Proc Natl Acad Sci U S A 2017[Feb]; 114 (9): E1698-706 PMID28193861show ga To combat infections with bacterial pathogens that reside and replicate inside specialized intracellular vacuoles, the innate immune system must be able to distinguish these pathogen-containing vacuoles (PVs) from endogenous vesicles. Here, we demonstrate that the host can detect the presence of bacterial secretion systems as hallmarks of PVs. The insertion of bacterial protein secretion pores destabilizes vesicular membranes, allowing host carbohydrate-binding proteins to access the sugar-decorated luminal side of vacuolar membranes. We show that a specific carbohydrate-binding protein recruits members of a family of antimicrobial GTPases to PVs. Our findings reveal how host cells deliver antimicrobial defenses specifically to intracellular vesicles occupied by pathogens. äGalectin-3 directs antimicrobial guanylate binding proteins to vacuole(epmc).pdf DeepDyve Pubget Overpricing