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10.18632/oncotarget.12229 http://scihub22266oqcxt.onion/10.18632/oncotarget.12229 C5342096!5342096!27683030     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27683030&cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNA regulatory pathway analysis identifies miR-142-5p as a negative regulator of TGF-? pathway via targeting SMAD3 |pdf=|usr=}}{{27683030}} gab.com Text MicroRNA regulatory pathway analysis identifies miR-142-5p as a negative regulator of TGF- pathway via targeting SMAD3 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27683030 #FOAvip MicroRNAs (miRNAs) are non-coding RNAs with functions of posttranscriptional regulation. The abnormally expressed miRNAs have been shown to be crucial contributors and may serve as biomarkers in many diseases. However, determining the biological function of miRNAs is an ongoing challenge. By combining miRNA targets prediction, miRNA and mRNA expression profiles in TCGA cancers, and pathway data, we performed a miRNA-pathway regulation inference by Fisher's exact test for enrichment analysis. Then we constructed a database to show the cancer related miRNA-pathway regulatory network (http://bioinfo.life.hust.edu.cn/miR_path). As one of the miRNAs targeting many cancer related pathways, miR-142-5p potentially regulates the maximum number of genes in TGF-? signaling pathway. We experimentally confirmed that miR-142-5p directly targeted and suppressed SMAD3, a key component in TGF-? signaling. Ectopic overexpression of miR-142-5p significantly promoted tumor cell proliferation and inhibited apoptosis, while silencing of miR-142-5p inhibited the tumor cell proliferation and promoted apoptosis in vitro. These findings indicate that miR-142-5p plays as a negative regulator in TGF-? pathway by targeting SMAD3 and suppresses TGF-?-induced growth inhibition in cancer cells. Our study proved the feasibility of miRNA regulatory pathway analysis and shed light on combining bioinformatics with experiments in the research of complex diseases. Twit Text FOAVip MicroRNA regulatory pathway analysis identifies miR-142-5p as a negative regulator of TGF- pathway via targeting SMAD3 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27683030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27683030 #FOAvip English Wikipedia <ref>{{Cite pmid|27683030}}</ref> MicroRNA regulatory pathway analysis identifies miR-142-5p as a negative regulator of TGF-? pathway via targeting SMAD3 #MMPMID27683030 Ma Z; Liu T; Huang W; Liu H; Zhang HM; Li Q; Chen Z; Guo AY Oncotarget 2016[Nov]; 7 (44): 71504-13 PMID27683030show ga MicroRNAs (miRNAs) are non-coding RNAs with functions of posttranscriptional regulation. The abnormally expressed miRNAs have been shown to be crucial contributors and may serve as biomarkers in many diseases. However, determining the biological function of miRNAs is an ongoing challenge. By combining miRNA targets prediction, miRNA and mRNA expression profiles in TCGA cancers, and pathway data, we performed a miRNA-pathway regulation inference by Fisher's exact test for enrichment analysis. Then we constructed a database to show the cancer related miRNA-pathway regulatory network (http://bioinfo.life.hust.edu.cn/miR_path). As one of the miRNAs targeting many cancer related pathways, miR-142-5p potentially regulates the maximum number of genes in TGF-? signaling pathway. We experimentally confirmed that miR-142-5p directly targeted and suppressed SMAD3, a key component in TGF-? signaling. Ectopic overexpression of miR-142-5p significantly promoted tumor cell proliferation and inhibited apoptosis, while silencing of miR-142-5p inhibited the tumor cell proliferation and promoted apoptosis in vitro. These findings indicate that miR-142-5p plays as a negative regulator in TGF-? pathway by targeting SMAD3 and suppresses TGF-?-induced growth inhibition in cancer cells. Our study proved the feasibility of miRNA regulatory pathway analysis and shed light on combining bioinformatics with experiments in the research of complex diseases. äMicroRNA regulatory pathway analysis identifies miR-142-5p as a negati(epmc).pdf DeepDyve Pubget Overpricing