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10.18632/oncotarget.12253 http://scihub22266oqcxt.onion/10.18632/oncotarget.12253 C5342101!5342101!27689400     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27689400&cmd=llinks): Failed to open stream: HTTP request failed! 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Long noncoding RNA uc 345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression |pdf=|usr=}}{{27689400}} gab.com Text Long noncoding RNA uc 345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27689400 #FOAvip Increasing evidence points to an important functional or regulatory role of long noncoding RNA in cellular processes as well as cancer diseases resulted from the aberrant lncRNA expression. LncRNA could participate in the cancer progression and develop a significant role through the interaction with proteins. In the present study, we report a lncRNA termed uc.345 that is up-regulated in tumor tissues, compared to the corresponding noncancerous tissues. We found that a higher uc.345 expression level was more frequently observed in tissues with increased depth of invasion and advanced TNM tumor node metastasis T stage. Moreover, uc.345 could be used as an independent risk factor for the overall survival (OS) of the pancreatic cancer patients. By employing soft agar assays and tumor xenograft models, we showed that uc.345 could accelerate tumor growth. Further, we discovered that uc.345 could upregulate the hnRNPL expression and that inhibition of (hnRNPL) dampens the tumorigenesis capability of uc.345. Collectively, these results demonstrate that uc.345 functions as an oncogenic lncRNA that promotes tumor progression and serves as a poor predictor for pancreatic cancer patients' overall survival. Twit Text FOAVip Long noncoding RNA uc 345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27689400 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27689400 #FOAvip English Wikipedia <ref>{{Cite pmid|27689400}}</ref> Long noncoding RNA uc 345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression #MMPMID27689400 Liu C; Wang J; Yuan X; Qian W; Zhang B; Shi M; Xie J; Shen B; Xu H; Hou Z; Chen H Oncotarget 2016[Nov]; 7 (44): 71556-66 PMID27689400show ga Increasing evidence points to an important functional or regulatory role of long noncoding RNA in cellular processes as well as cancer diseases resulted from the aberrant lncRNA expression. LncRNA could participate in the cancer progression and develop a significant role through the interaction with proteins. In the present study, we report a lncRNA termed uc.345 that is up-regulated in tumor tissues, compared to the corresponding noncancerous tissues. We found that a higher uc.345 expression level was more frequently observed in tissues with increased depth of invasion and advanced TNM tumor node metastasis T stage. Moreover, uc.345 could be used as an independent risk factor for the overall survival (OS) of the pancreatic cancer patients. By employing soft agar assays and tumor xenograft models, we showed that uc.345 could accelerate tumor growth. Further, we discovered that uc.345 could upregulate the hnRNPL expression and that inhibition of (hnRNPL) dampens the tumorigenesis capability of uc.345. Collectively, these results demonstrate that uc.345 functions as an oncogenic lncRNA that promotes tumor progression and serves as a poor predictor for pancreatic cancer patients' overall survival. äLong noncoding RNA uc 345 promotes tumorigenesis of pancreatic cancer (epmc).pdf DeepDyve Pubget Overpricing