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10.18632/oncotarget.12779 http://scihub22266oqcxt.onion/10.18632/oncotarget.12779 C5342809!5342809!27776350     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27776350&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27776350.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (46): 76224-37 Nephropedia Template TP {{tp|p=27776350|t=2016. Focal adhesion molecule Kindlin-1 mediates activation of TGF-? signaling by interacting with TGF-?RI, SARA and Smad3 in colorectal cancer cells |pdf=|usr=}}{{27776350}} gab.com Text Focal adhesion molecule Kindlin-1 mediates activation of TGF- signaling by interacting with TGF- RI, SARA and Smad3 in colorectal cancer cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27776350 #FOAvip Kindlin-1, an integrin-interacting protein, has been implicated in TGF-?/Smad3 signaling. However, the molecular mechanism underlying Kindlin-1 regulation of TGF-?/Smad3 signaling remains elusive. Here, we reported that Kindlin-1 is an important mediator of TGF-?/Smad3 signaling by showing that Kindlin-1 physically interacts with TGF-? receptor I (T?RI), Smad anchor for receptor activation (SARA) and Smad3. Kindlin-1 is required for the interaction of Smad3 with T?RI, Smad3 phosphorylation, nuclear translocation, and finally the activation of TGF-?/Smad3 signaling pathway. Functionally, Kindlin-1 promoted colorectal cancer (CRC) cell proliferation in vitro and tumor growth in vivo, and was also required for CRC cell migration and invasion via an epithelial to mesenchymal transition. Kindlin-1 was found to be increased with the CRC progression from stages I to IV. Importantly, raised expression level of Kindlin-1 correlates with poor outcome in CRC patients. Taken together, we demonstrated that Kindlin-1 promotes CRC progression by recruiting SARA and Smad3 to T?RI and thereby activates TGF-?/Smad3 signaling. Thus, Kindlin-1 is a novel regulator of TGF-?/Smad3 signaling and may also be a potential target for CRC therapeutics. Twit Text FOAVip Focal adhesion molecule Kindlin-1 mediates activation of TGF- signaling by interacting with TGF- RI, SARA and Smad3 in colorectal cancer cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27776350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27776350 #FOAvip English Wikipedia <ref>{{Cite pmid|27776350}}</ref> Focal adhesion molecule Kindlin-1 mediates activation of TGF-? signaling by interacting with TGF-?RI, SARA and Smad3 in colorectal cancer cells #MMPMID27776350 Kong J; Du J; Wang Y; Yang M; Gao J; Wei X; Fang W; Zhan J; Zhang H Oncotarget 2016[Nov]; 7 (46): 76224-37 PMID27776350show ga Kindlin-1, an integrin-interacting protein, has been implicated in TGF-?/Smad3 signaling. However, the molecular mechanism underlying Kindlin-1 regulation of TGF-?/Smad3 signaling remains elusive. Here, we reported that Kindlin-1 is an important mediator of TGF-?/Smad3 signaling by showing that Kindlin-1 physically interacts with TGF-? receptor I (T?RI), Smad anchor for receptor activation (SARA) and Smad3. Kindlin-1 is required for the interaction of Smad3 with T?RI, Smad3 phosphorylation, nuclear translocation, and finally the activation of TGF-?/Smad3 signaling pathway. Functionally, Kindlin-1 promoted colorectal cancer (CRC) cell proliferation in vitro and tumor growth in vivo, and was also required for CRC cell migration and invasion via an epithelial to mesenchymal transition. Kindlin-1 was found to be increased with the CRC progression from stages I to IV. Importantly, raised expression level of Kindlin-1 correlates with poor outcome in CRC patients. Taken together, we demonstrated that Kindlin-1 promotes CRC progression by recruiting SARA and Smad3 to T?RI and thereby activates TGF-?/Smad3 signaling. Thus, Kindlin-1 is a novel regulator of TGF-?/Smad3 signaling and may also be a potential target for CRC therapeutics. äFocal adhesion molecule Kindlin-1 mediates activation of TGF-? signali(epmc).pdf DeepDyve Pubget Overpricing