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10.1038/srep44824 http://scihub22266oqcxt.onion/10.1038/srep44824 C5356003!5356003!28303941     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28303941&cmd=llinks): Failed to open stream: HTTP request failed! 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Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis |pdf=|usr=}}{{28303941}} gab.com Text Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28303941 #FOAvip Intact bone tissue exhibits a characteristic anisotropic microstructure derived from collagen fiber alignment and the related c-axis orientation of apatite crystals, which govern the mechanical properties of bone tissue. In contrast, tumor-invaded bone exhibits a disorganized, less-aligned microstructure that results in severely disrupted mechanical function. Despite its importance both in basic principle and in therapeutic applications, the classical understanding of bone metastasis is limited to alterations in bone mass regulated by metastatic cancer cells. In this study, we demonstrate a novel mechanism underlying the disruption of bone tissue anisotropy in metastasized bone. We observed that direct attack by cancer cells on osteoblasts induces the less-organized osteoblast arrangement. Importantly, the crystallographic anisotropy of bone tissue is quantitatively determined by the level of osteoblast arrangement. Osteoblast arrangement was significantly disrupted by physical contact with cancer cells such as osteolytic melanoma B16F10, breast cancer MDA-MB-231, and osteoblastic prostate cancer MDA-PCa-2b cells. The present findings demonstrate that the abnormal arrangement of osteoblasts induced by physical contact with cancer cells facilitates the disorganized microstructure of metastasized bone. Twit Text FOAVip Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28303941 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28303941 #FOAvip English Wikipedia <ref>{{Cite pmid|28303941}}</ref> Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis #MMPMID28303941 Kimura Y; Matsugaki A; Sekita A; Nakano T Sci Rep 2017[]; 7 (ä): ä PMID28303941show ga Intact bone tissue exhibits a characteristic anisotropic microstructure derived from collagen fiber alignment and the related c-axis orientation of apatite crystals, which govern the mechanical properties of bone tissue. In contrast, tumor-invaded bone exhibits a disorganized, less-aligned microstructure that results in severely disrupted mechanical function. Despite its importance both in basic principle and in therapeutic applications, the classical understanding of bone metastasis is limited to alterations in bone mass regulated by metastatic cancer cells. In this study, we demonstrate a novel mechanism underlying the disruption of bone tissue anisotropy in metastasized bone. We observed that direct attack by cancer cells on osteoblasts induces the less-organized osteoblast arrangement. Importantly, the crystallographic anisotropy of bone tissue is quantitatively determined by the level of osteoblast arrangement. Osteoblast arrangement was significantly disrupted by physical contact with cancer cells such as osteolytic melanoma B16F10, breast cancer MDA-MB-231, and osteoblastic prostate cancer MDA-PCa-2b cells. The present findings demonstrate that the abnormal arrangement of osteoblasts induced by physical contact with cancer cells facilitates the disorganized microstructure of metastasized bone. äAlteration of osteoblast arrangement via direct attack by cancer cells(epmc).pdf DeepDyve Pubget Overpricing