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10.18632/oncotarget.11968 http://scihub22266oqcxt.onion/10.18632/oncotarget.11968 C5356589!5356589!27634891     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27634891&cmd=llinks): Failed to open stream: HTTP request failed! 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CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3? signaling pathway |pdf=|usr=}}{{27634891}} gab.com Text CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3 signaling pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27634891 #FOAvip The pharmacological activation of the cannabinoid receptor type 2, CB2, has been shown to elicit anti-tumoral mechanisms in different cancer types. However, little is known about its endogenous role in tumor pathophysiology, and different studies have attributed pro-tumorigenic properties to this receptor. In a previous work, we showed that CB2 expression is a poor prognostic factor in colon cancer patients. Here we report that activation of CB2 with low doses of specific agonists induce cell proliferation and favor the acquisition of aggressive molecular features in colon cancer cells. We show that sub-micromolar concentrations of CB2-specific agonists, JWH-133 and HU-308, promote an increase in cell proliferation rate through the activation of AKT/PKB pathway in colon cancer in vitro and in vivo. AKT activation promotes GSK3? inhibition and thus, a more aggressive cell phenotype with the subsequent elevation of SNAIL levels, E-cadherin degradation and ?-catenin delocalization from cell membrane. Taken together, our data show that CB2 activation with sub-micromolar doses of agonists, which could be more similar to endogenous levels of cannabinoids, promote colon cancer progression, implicating that CB2 could have a pro-tumorigenic endogenous role in colon cancer. Twit Text FOAVip CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3 signaling pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27634891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27634891 #FOAvip English Wikipedia <ref>{{Cite pmid|27634891}}</ref> CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3? signaling pathway #MMPMID27634891 Martínez-Martínez E; Martín-Ruiz A; Martín P; Calvo V; Provencio M; García JM Oncotarget 2016[Oct]; 7 (42): 68781-91 PMID27634891show ga The pharmacological activation of the cannabinoid receptor type 2, CB2, has been shown to elicit anti-tumoral mechanisms in different cancer types. However, little is known about its endogenous role in tumor pathophysiology, and different studies have attributed pro-tumorigenic properties to this receptor. In a previous work, we showed that CB2 expression is a poor prognostic factor in colon cancer patients. Here we report that activation of CB2 with low doses of specific agonists induce cell proliferation and favor the acquisition of aggressive molecular features in colon cancer cells. We show that sub-micromolar concentrations of CB2-specific agonists, JWH-133 and HU-308, promote an increase in cell proliferation rate through the activation of AKT/PKB pathway in colon cancer in vitro and in vivo. AKT activation promotes GSK3? inhibition and thus, a more aggressive cell phenotype with the subsequent elevation of SNAIL levels, E-cadherin degradation and ?-catenin delocalization from cell membrane. Taken together, our data show that CB2 activation with sub-micromolar doses of agonists, which could be more similar to endogenous levels of cannabinoids, promote colon cancer progression, implicating that CB2 could have a pro-tumorigenic endogenous role in colon cancer. äCB2 cannabinoid receptor activation promotes colon cancer progression (epmc).pdf DeepDyve Pubget Overpricing