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10.1038/srep44708 http://scihub22266oqcxt.onion/10.1038/srep44708 C5357787!5357787!28317877     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28317877&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28317877.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28317877|t=2017. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions |pdf=|usr=}}{{28317877}} gab.com Text Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28317877 #FOAvip Mitochondria are intracellular organelles involved in cell survival and death, and dysfunctions of mitochondria are related to neurodegenerative diseases. As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial function, including the exchange of adenosine triphosphate/adenosine diphosphate (ATP/ADP) in mitochondria, basal proton leak and mitochondrial permeability transition pore (mPTP). Here, we show that ANT1 transcription is regulated by transcription factor NF-kappa B (NF-?B). NF-?B is bound to two NF-?B responsive elements (NREs) located at +1 to +20?bp and +41 to +61?bp in the ANT1 promoter. An NF-?B signalling stimulator, tumour necrosis factor alpha (TNF?), suppresses ANT1 mRNA and protein expression. Activation of NF-?B by TNF? impairs ATP/ADP exchange and decreases ATP production in mitochondria. Activation of NF-?B by TNF? decreases calcium induced mPTP opening, elevates mitochondrial potential and increases reactive oxygen species (ROS) production in both T98G human glioblastoma cells and rat cortical neurons. These results demonstrate that NF-?B signalling may repress ANT1 gene transcription and impair mitochondrial functions. Twit Text FOAVip Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28317877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28317877 #FOAvip English Wikipedia <ref>{{Cite pmid|28317877}}</ref> Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions #MMPMID28317877 Zhang C; Jiang H; Wang P; Liu H; Sun X Sci Rep 2017[]; 7 (ä): ä PMID28317877show ga Mitochondria are intracellular organelles involved in cell survival and death, and dysfunctions of mitochondria are related to neurodegenerative diseases. As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial function, including the exchange of adenosine triphosphate/adenosine diphosphate (ATP/ADP) in mitochondria, basal proton leak and mitochondrial permeability transition pore (mPTP). Here, we show that ANT1 transcription is regulated by transcription factor NF-kappa B (NF-?B). NF-?B is bound to two NF-?B responsive elements (NREs) located at +1 to +20?bp and +41 to +61?bp in the ANT1 promoter. An NF-?B signalling stimulator, tumour necrosis factor alpha (TNF?), suppresses ANT1 mRNA and protein expression. Activation of NF-?B by TNF? impairs ATP/ADP exchange and decreases ATP production in mitochondria. Activation of NF-?B by TNF? decreases calcium induced mPTP opening, elevates mitochondrial potential and increases reactive oxygen species (ROS) production in both T98G human glioblastoma cells and rat cortical neurons. These results demonstrate that NF-?B signalling may repress ANT1 gene transcription and impair mitochondrial functions. äTranscription factor NF-kappa B represses ANT1 transcription and leads(epmc).pdf DeepDyve Pubget Overpricing