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10.1161/ATVBAHA.117.307263 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.117.307263 C5364055!5364055!28183700     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28183700.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arterioscler+Thromb+Vasc+Biol 2017 ; 37 (4): 613-21 Nephropedia Template TP {{tp|p=28183700|t=2017. RAGE and Implications for the Pathogenesis and Treatment of Cardiometabolic Disorders ? Spotlight on the Macrophage |pdf=|usr=}}{{28183700}} gab.com Text RAGE and Implications for the Pathogenesis and Treatment of Cardiometabolic Disorders Spotlight on the Macrophage JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=28183700 #FOAvip The receptor for advanced glycation endproducts (RAGE) interacts with a unique repertoire of ligands that form and collect in the tissues and circulation in diabetes, aging, inflammation, renal failure and obesity. RAGE is expressed on multiple cell types linked to tissue perturbation in these settings. This Brief Review focuses on the role of RAGE in monocytes/macrophages and how RAGE ligand engagement on these cells mediates seminal changes in monocyte/macrophage migration, oxidative stress, cholesterol efflux and pro- vs. anti-inflammatory cues that signal to tissue damage. Studies using mice devoid of Ager (gene encoding RAGE) or pharmacological antagonists of RAGE are protective in animal models of diabetes, atherosclerosis, and high fat diet-induced obesity, in least in part through key roles in monocytes/macrophages. RAGE signal transduction requires the interaction of RAGE cytoplasmic domain with the formin, DIAPH1 and novel antagonists of this interaction show significant promise in attenuation of the maladaptive effects of RAGE ligands in cellular and in vivo models. Finally, this Brief Review discusses evidence for RAGE axis perturbation in human monocytes/macrophages and how tracing RAGE activity in these cells may identify target engagement biomarkers of RAGE antagonism for future clinical trials. Twit Text FOAVip RAGE and Implications for the Pathogenesis and Treatment of Cardiometabolic Disorders Spotlight on the Macrophage ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=28183700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28183700 #FOAvip English Wikipedia <ref>{{Cite pmid|28183700}}</ref> RAGE and Implications for the Pathogenesis and Treatment of Cardiometabolic Disorders ? Spotlight on the Macrophage #MMPMID28183700 Schmidt AM Arterioscler Thromb Vasc Biol 2017[Apr]; 37 (4): 613-21 PMID28183700show ga The receptor for advanced glycation endproducts (RAGE) interacts with a unique repertoire of ligands that form and collect in the tissues and circulation in diabetes, aging, inflammation, renal failure and obesity. RAGE is expressed on multiple cell types linked to tissue perturbation in these settings. This Brief Review focuses on the role of RAGE in monocytes/macrophages and how RAGE ligand engagement on these cells mediates seminal changes in monocyte/macrophage migration, oxidative stress, cholesterol efflux and pro- vs. anti-inflammatory cues that signal to tissue damage. Studies using mice devoid of Ager (gene encoding RAGE) or pharmacological antagonists of RAGE are protective in animal models of diabetes, atherosclerosis, and high fat diet-induced obesity, in least in part through key roles in monocytes/macrophages. RAGE signal transduction requires the interaction of RAGE cytoplasmic domain with the formin, DIAPH1 and novel antagonists of this interaction show significant promise in attenuation of the maladaptive effects of RAGE ligands in cellular and in vivo models. Finally, this Brief Review discusses evidence for RAGE axis perturbation in human monocytes/macrophages and how tracing RAGE activity in these cells may identify target engagement biomarkers of RAGE antagonism for future clinical trials. äRAGE and Implications for the Pathogenesis and Treatment of Cardiometa(epmc).pdf DeepDyve Pubget Overpricing