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10.3892/mmr.2017.6179 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6179 C5364971!5364971!28259900     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28259900&cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNA-185 regulates transforming growth factor-?1 and collagen-1 in hypertrophic scar fibroblasts |pdf=|usr=}}{{28259900}} gab.com Text MicroRNA-185 regulates transforming growth factor- 1 and collagen-1 in hypertrophic scar fibroblasts JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28259900 #FOAvip Transforming growth factor-?1 (TGF-?1) and collagen type I (Col-1) serve a critical role in the development and progression of hypertrophic scarring (HS). The present study hypothesized that a post-translational mechanism of microRNAs (miR) regulated the expression of TGF-?1 and Col-1 in HS fibroblasts (HSFBs). A collection of 20 HS tissues was compared with corresponding normal tissues from clinical patients, and the expression of miR-185 was measured. Using PicTar, TargetScan and miRBase databases, it was identified that miR-185 may be a regulator of TGF-?1 and Col-1 in humans. Based on these hypotheses, the expression of miR-185, TGF-?1 and Col-1 in HS tissues was investigated. The results demonstrated that the expression of miR-185 was markedly suppressed, and TGF-?1 and Col-1 levels were increased, in HS tissues. The expression levels of endogenous miR-185 negatively correlated with the TGF-?1 and Col-1 mRNA levels (Pearson's correlation coefficient r=?0.674, P<0.01 and r=?0.590, P<0.01, respectively). In vitro, miR-185 can regulate TGF-?1 and Col-1 through the predicted binding sites in its 3?-untranslated region. miR-185 had an effect on cell proliferation and apoptosis, thereby regulating HSFBs growth. In addition, miR-185 gain-of-function decreased TGF-?1 and Col-1 protein expression, and miR-185 loss-of-function increased TGF-?1 and Col-1 protein expression in HSFBs. In conclusion, overexpressed miR-185 could inhibit HSFBs growth, and the underlying mechanism was mediated, at least partly, through the suppression of TGF-?1 and Col-1 expression. However, above all, miR-185 might serve as a potential therapeutic approach for the treatment of HS. Twit Text FOAVip MicroRNA-185 regulates transforming growth factor- 1 and collagen-1 in hypertrophic scar fibroblasts ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28259900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28259900 #FOAvip English Wikipedia <ref>{{Cite pmid|28259900}}</ref> MicroRNA-185 regulates transforming growth factor-?1 and collagen-1 in hypertrophic scar fibroblasts #MMPMID28259900 Xiao K; Luo X; Wang X; Gao Z Mol Med Rep 2017[Apr]; 15 (4): 1489-96 PMID28259900show ga Transforming growth factor-?1 (TGF-?1) and collagen type I (Col-1) serve a critical role in the development and progression of hypertrophic scarring (HS). The present study hypothesized that a post-translational mechanism of microRNAs (miR) regulated the expression of TGF-?1 and Col-1 in HS fibroblasts (HSFBs). A collection of 20 HS tissues was compared with corresponding normal tissues from clinical patients, and the expression of miR-185 was measured. Using PicTar, TargetScan and miRBase databases, it was identified that miR-185 may be a regulator of TGF-?1 and Col-1 in humans. Based on these hypotheses, the expression of miR-185, TGF-?1 and Col-1 in HS tissues was investigated. The results demonstrated that the expression of miR-185 was markedly suppressed, and TGF-?1 and Col-1 levels were increased, in HS tissues. The expression levels of endogenous miR-185 negatively correlated with the TGF-?1 and Col-1 mRNA levels (Pearson's correlation coefficient r=?0.674, P<0.01 and r=?0.590, P<0.01, respectively). In vitro, miR-185 can regulate TGF-?1 and Col-1 through the predicted binding sites in its 3?-untranslated region. miR-185 had an effect on cell proliferation and apoptosis, thereby regulating HSFBs growth. In addition, miR-185 gain-of-function decreased TGF-?1 and Col-1 protein expression, and miR-185 loss-of-function increased TGF-?1 and Col-1 protein expression in HSFBs. In conclusion, overexpressed miR-185 could inhibit HSFBs growth, and the underlying mechanism was mediated, at least partly, through the suppression of TGF-?1 and Col-1 expression. However, above all, miR-185 might serve as a potential therapeutic approach for the treatment of HS. äMicroRNA-185 regulates transforming growth factor-?1 and collagen-1 in(epmc).pdf DeepDyve Pubget Overpricing