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10.3349/ymj.2017.58.3.604

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suck abstract from ncbi


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pmid28332367      Yonsei+Med+J 2017 ; 58 (3): 604-12
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  • Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery #MMPMID28332367
  • Leem AY; Park MS; Park BH; Jung WJ; Chung KS; Kim SY; Kim EY; Jung JY; Kang YA; Kim YS; Kim SK; Chang J; Song JH
  • Yonsei Med J 2017[May]; 58 (3): 604-12 PMID28332367show ga
  • Purpose: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. Materials and Methods: Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. Results: Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidence interval (CI)= 2.58?144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00?2.68, p=0.048) were associated with recovery of AKI. Conclusion: Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.
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