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10.7150/ijms.17718 http://scihub22266oqcxt.onion/10.7150/ijms.17718 C5370281!5370281!28367079     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28367079&cmd=llinks): Failed to open stream: HTTP request failed! 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Reviewing primary Sj�gren s syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment |pdf=|usr=}}{{28367079}} gab.com Text Reviewing primary Sj�gren s syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment JO: Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28367079 #FOAvip Primary Sj�gren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vagina. Extraglandular manifestations may also be prevalent in patients with pSS, including cutaneous, musculoskeletal, pulmonary, renal, hematological and neurological involvement. The pathogenesis of pSS is currently not well understood, but increased activation of B cells followed by immune complex formation and autoantibody production are thought to play important roles. pSS is diagnosed using the American-European consensus group (AECG) classification criteria which include subjective symptoms and objective tests such as histopathology and serology. The treatment of pSS warrants an organ based approach, for which local treatment (teardrops, moistures) and systemic therapy (including non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDS) and biologicals) can be considered. Biologicals used in the treatment of pSS mainly affect the total numbers of B cells (B cell depletion (Rituximab)) or target proteins required for B cell proliferation and/or activation (e.g. B cell activating factor (BAFF)) resulting in decreased B cell activity.The aim of this review is to provide physicians a general overview concerning the pathogenesis, diagnosis and management of pSS patients. Twit Text FOAVip Reviewing primary Sj�gren s syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment ????Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28367079 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28367079 #FOAvip English Wikipedia <ref>{{Cite pmid|28367079}}</ref> Reviewing primary Sj�gren s syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment #MMPMID28367079 Both T; Dalm VA; van Hagen PM; van Daele PL Int J Med Sci 2017[]; 14 (3): 191-200 PMID28367079show ga Primary Sj�gren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vagina. Extraglandular manifestations may also be prevalent in patients with pSS, including cutaneous, musculoskeletal, pulmonary, renal, hematological and neurological involvement. The pathogenesis of pSS is currently not well understood, but increased activation of B cells followed by immune complex formation and autoantibody production are thought to play important roles. pSS is diagnosed using the American-European consensus group (AECG) classification criteria which include subjective symptoms and objective tests such as histopathology and serology. The treatment of pSS warrants an organ based approach, for which local treatment (teardrops, moistures) and systemic therapy (including non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDS) and biologicals) can be considered. Biologicals used in the treatment of pSS mainly affect the total numbers of B cells (B cell depletion (Rituximab)) or target proteins required for B cell proliferation and/or activation (e.g. B cell activating factor (BAFF)) resulting in decreased B cell activity.The aim of this review is to provide physicians a general overview concerning the pathogenesis, diagnosis and management of pSS patients. �Reviewing primary Sj�gren s syndrome: beyond the dryness - From pathop(epmc).pdf DeepDyve Pubget Overpricing