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10.1038/srep45474 http://scihub22266oqcxt.onion/10.1038/srep45474 C5371822!5371822!28358017     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28358017&cmd=llinks): Failed to open stream: HTTP request failed! 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Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging |pdf=|usr=}}{{28358017}} gab.com Text Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28358017 #FOAvip Within mitochondria, the ability to produce energy relies upon the architectural hallmarks of double membranes and cristae invaginations. Herein, we describe novel features of mitochondrial cristae structure, which correspond to the energetic state of the organelle. In concordance with high-energy demand, mitochondria of Drosophila indirect flight muscle exhibited extensive intra-mitochondrial membrane switches between densely packed lamellar cristae that resulted in a spiral-like cristae network and allowed for bidirectional matrix confluency. This highly interconnected architecture is expected to allow rapid equilibration of membrane potential and biomolecules across integrated regions. In addition, mutant flies with mtDNA replication defect and an accelerated aging phenotype accumulated mitochondria that contained subsections of swirling membrane alongside normal cristae. The swirling membrane had impaired energy production capacity as measured by protein composition and function. Furthermore, mitochondrial fusion and fission dynamics were affected in the prematurely aged flies. Interestingly, the normal cristae that remained in the mitochondria with swirling membranes maintained acceptable function that camouflaged them from quality control elimination. Overall, structural features of mitochondrial cristae were described in three-dimension from serial section electron tomographic analysis which reflect energetic state and mtDNA-mediated aging. Twit Text FOAVip Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28358017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28358017 #FOAvip English Wikipedia <ref>{{Cite pmid|28358017}}</ref> Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging #MMPMID28358017 Jiang Yf; Lin Ss; Chen Jm; Tsai Hz; Hsieh Ts; Fu Cy Sci Rep 2017[]; 7 (ä): ä PMID28358017show ga Within mitochondria, the ability to produce energy relies upon the architectural hallmarks of double membranes and cristae invaginations. Herein, we describe novel features of mitochondrial cristae structure, which correspond to the energetic state of the organelle. In concordance with high-energy demand, mitochondria of Drosophila indirect flight muscle exhibited extensive intra-mitochondrial membrane switches between densely packed lamellar cristae that resulted in a spiral-like cristae network and allowed for bidirectional matrix confluency. This highly interconnected architecture is expected to allow rapid equilibration of membrane potential and biomolecules across integrated regions. In addition, mutant flies with mtDNA replication defect and an accelerated aging phenotype accumulated mitochondria that contained subsections of swirling membrane alongside normal cristae. The swirling membrane had impaired energy production capacity as measured by protein composition and function. Furthermore, mitochondrial fusion and fission dynamics were affected in the prematurely aged flies. Interestingly, the normal cristae that remained in the mitochondria with swirling membranes maintained acceptable function that camouflaged them from quality control elimination. Overall, structural features of mitochondrial cristae were described in three-dimension from serial section electron tomographic analysis which reflect energetic state and mtDNA-mediated aging. äElectron tomographic analysis reveals ultrastructural features of mito(epmc).pdf DeepDyve Pubget Overpricing