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10.1172/JCI87993 http://scihub22266oqcxt.onion/10.1172/JCI87993 C5373894!5373894!28319051     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28319051&cmd=llinks): Failed to open stream: HTTP request failed! 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Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue |pdf=|usr=}}{{28319051}} gab.com Text Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28319051 #FOAvip In transplantation, there is a critical need for noninvasive biomarker platforms for monitoring immunologic rejection. We hypothesized that transplanted tissues release donor-specific exosomes into recipient circulation and that the quantitation and profiling of donor intra-exosomal cargoes may constitute a biomarker platform for monitoring rejection. Here, we have tested this hypothesis in a human-into-mouse xenogeneic islet transplant model and validated the concept in clinical settings of islet and renal transplantation. In the xenogeneic model, we quantified islet transplant exosomes in recipient blood over long-term follow-up using anti-HLA antibody, which was detectable only in xenoislet recipients of human islets. Transplant islet exosomes were purified using anti-HLA antibody?conjugated beads, and their cargoes contained the islet endocrine hormone markers insulin, glucagon, and somatostatin. Rejection led to a marked decrease in transplant islet exosome signal along with distinct changes in exosomal microRNA and proteomic profiles prior to appearance of hyperglycemia. In the clinical settings of islet and renal transplantation, donor exosomes with respective tissue specificity for islet ? cells and renal epithelial cells were reliably characterized in recipient plasma over follow-up periods of up to 5 years. Collectively, these findings demonstrate the biomarker potential of transplant exosome characterization for providing a noninvasive window into the conditional state of transplant tissue. Twit Text FOAVip Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28319051 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28319051 #FOAvip English Wikipedia <ref>{{Cite pmid|28319051}}</ref> Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue #MMPMID28319051 Vallabhajosyula P; Korutla L; Habertheuer A; Yu M; Rostami S; Yuan CX; Reddy S; Liu C; Korutla V; Koeberlein B; Trofe-Clark J; Rickels MR; Naji A J Clin Invest ä[]; 127 (4): 1375-91 PMID28319051show ga In transplantation, there is a critical need for noninvasive biomarker platforms for monitoring immunologic rejection. We hypothesized that transplanted tissues release donor-specific exosomes into recipient circulation and that the quantitation and profiling of donor intra-exosomal cargoes may constitute a biomarker platform for monitoring rejection. Here, we have tested this hypothesis in a human-into-mouse xenogeneic islet transplant model and validated the concept in clinical settings of islet and renal transplantation. In the xenogeneic model, we quantified islet transplant exosomes in recipient blood over long-term follow-up using anti-HLA antibody, which was detectable only in xenoislet recipients of human islets. Transplant islet exosomes were purified using anti-HLA antibody?conjugated beads, and their cargoes contained the islet endocrine hormone markers insulin, glucagon, and somatostatin. Rejection led to a marked decrease in transplant islet exosome signal along with distinct changes in exosomal microRNA and proteomic profiles prior to appearance of hyperglycemia. In the clinical settings of islet and renal transplantation, donor exosomes with respective tissue specificity for islet ? cells and renal epithelial cells were reliably characterized in recipient plasma over follow-up periods of up to 5 years. Collectively, these findings demonstrate the biomarker potential of transplant exosome characterization for providing a noninvasive window into the conditional state of transplant tissue. äTissue-specific exosome biomarkers for noninvasively monitoring immuno(epmc).pdf DeepDyve Pubget Overpricing