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10.1042/BST20150225

http://scihub22266oqcxt.onion/10.1042/BST20150225
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C5380233!5380233!26862216
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suck abstract from ncbi


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pmid26862216      Biochem+Soc+Trans 2016 ; 44 (1): 279-85
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  • Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism #MMPMID26862216
  • Malabanan MM; Blind RD
  • Biochem Soc Trans 2016[Feb]; 44 (1): 279-85 PMID26862216show ga
  • Inositol polyphosphate multikinase (IPMK, ipk2, Arg82, ArgRIII) is an inositide kinase with unusually flexible substrate specificity and the capacity to partake in many functional protein?protein interactions (PPIs). By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be recognized. In this short review, we present a brief history of IPMK, describe the structural biology of the enzyme and highlight a few recent discoveries that have shed more light on the role IPMK plays in inositide metabolism, nuclear signalling and transcriptional regulation.



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