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10.1371/journal.pone.0175593 http://scihub22266oqcxt.onion/10.1371/journal.pone.0175593 C5386292!5386292!28394947     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28394947.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (4): ä Nephropedia Template TP {{tp|p=28394947|t=2017. Hypoxia-inducible factor-2? stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2 |pdf=|usr=}}{{28394947}} gab.com Text Hypoxia-inducible factor-2 stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28394947 #FOAvip Ubiquitin ligase von Hippel?Lindau tumor suppressor (pVHL) negatively regulates protein levels of hypoxia-inducible factor-? (HIF-?). Loss of pVHL causes HIF-? accumulation, which contributes to the pathogenesis of von Hippel-Lindau (VHL) disease. In contrast, v-Myb avian myeloblastosis viral oncogene homolog?like 2 (MYBL2; B-Myb), a transcription factor, prevents VHL pathogenesis by regulating gene expression of HIF-independent pathways. Both HIF-? and B-Myb are targets of pVHL-mediated polyubiquitination and proteasomal degradation. Here, we show that knockdown of HIF-2? induces downregulation of B-Myb in 786-O cells, which are deficient in pVHL, and this downregulation is prevented by proteasome inhibition. In the presence of pVHL and under hypoxia-like conditions, B-Myb and HIF-2? are both upregulated, and the upregulation of B-Myb requires expression of HIF-2?. We also show that HIF-2? and B-Myb interact in the nucleus, and this interaction is mediated by the central region of HIF-2? and the C-terminal region of B-Myb. These data indicate that oncogenic HIF-2? stabilizes B-Myb to suppress VHL pathogenesis. Twit Text FOAVip Hypoxia-inducible factor-2 stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28394947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28394947 #FOAvip English Wikipedia <ref>{{Cite pmid|28394947}}</ref> Hypoxia-inducible factor-2? stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2 #MMPMID28394947 Okumura F; Joo-Okumura A; Nakatsukasa K; Kamura T PLoS One 2017[]; 12 (4): ä PMID28394947show ga Ubiquitin ligase von Hippel?Lindau tumor suppressor (pVHL) negatively regulates protein levels of hypoxia-inducible factor-? (HIF-?). Loss of pVHL causes HIF-? accumulation, which contributes to the pathogenesis of von Hippel-Lindau (VHL) disease. In contrast, v-Myb avian myeloblastosis viral oncogene homolog?like 2 (MYBL2; B-Myb), a transcription factor, prevents VHL pathogenesis by regulating gene expression of HIF-independent pathways. Both HIF-? and B-Myb are targets of pVHL-mediated polyubiquitination and proteasomal degradation. Here, we show that knockdown of HIF-2? induces downregulation of B-Myb in 786-O cells, which are deficient in pVHL, and this downregulation is prevented by proteasome inhibition. In the presence of pVHL and under hypoxia-like conditions, B-Myb and HIF-2? are both upregulated, and the upregulation of B-Myb requires expression of HIF-2?. We also show that HIF-2? and B-Myb interact in the nucleus, and this interaction is mediated by the central region of HIF-2? and the C-terminal region of B-Myb. These data indicate that oncogenic HIF-2? stabilizes B-Myb to suppress VHL pathogenesis. äHypoxia-inducible factor-2? stabilizes the von Hippel-Lindau (VHL) dis(epmc).pdf DeepDyve Pubget Overpricing