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10.1038/cddis.2017.103 http://scihub22266oqcxt.onion/10.1038/cddis.2017.103 C5386514!5386514!28300830     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28300830.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (3): e2681- Nephropedia Template TP {{tp|p=28300830|t=2017. Smad7 knockdown activates protein kinase RNA-associated eIF2? pathway leading to colon cancer cell death |pdf=|usr=}}{{28300830}} gab.com Text Smad7 knockdown activates protein kinase RNA-associated eIF2 pathway leading to colon cancer cell death JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28300830 #FOAvip Upregulation of Smad7, an inhibitor of transforming growth factor-?1 (TGF-?1), occurs in sporadic colorectal cancer (CRC) and knockdown of Smad7 inhibits CRC cell growth, a phenomenon that associates with decreased expression of cell division cycle 25 homolog A and arrest of cells in the S phase of the cell cycle. These findings occur in CRC cells unresponsive to TGF-?1, thus suggesting the existence of a Smad7-mediated TGF-?1-independent mechanism that controls CRC cell behavior. Here we show that Smad7 inhibition with a specific Smad7 antisense oligonucleotide upregulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation, a transcription factor involved in the regulation of cell cycle arrest and induction of cell death, and induces activating transcription factor 4 (ATF4) and CCAAT/enhancer binding protein homology protein (CHOP), two downstream targets of eIF2?. Among the upstream kinases that control eIF2? phosphorylation, the serine?threonine protein kinase RNA (PKR), but not general control non-derepressible 2 (GCN2) and protein kinase RNA-like endoplasmic reticulum kinase (PERK), is activated by Smad7 knockdown. PKR silencing abolishes Smad7 antisense-induced eIF2? phosphorylation and ATF4/CHOP induction, thereby preventing Smad7 antisense-driven cell death. Smad7 inhibition diminishes interaction of PKR with protein kinase inhibitor p58 (p58IPK), a cellular inhibitor of PKR, but does not change the expression and/or activity of other factors involved in the control of PKR activation. These findings delineate a novel mechanism by which Smad7 knockdown promotes CRC cell death. Twit Text FOAVip Smad7 knockdown activates protein kinase RNA-associated eIF2 pathway leading to colon cancer cell death ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28300830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28300830 #FOAvip English Wikipedia <ref>{{Cite pmid|28300830}}</ref> Smad7 knockdown activates protein kinase RNA-associated eIF2? pathway leading to colon cancer cell death #MMPMID28300830 De Simone V; Bevivino G; Sedda S; Izzo R; Laudisi F; Dinallo V; Franz� E; Colantoni A; Ortenzi A; Salvatori S; Rossi P; Sica GS; Fantini MC; Stolfi C; Monteleone G Cell Death Dis 2017[Mar]; 8 (3): e2681- PMID28300830show ga Upregulation of Smad7, an inhibitor of transforming growth factor-?1 (TGF-?1), occurs in sporadic colorectal cancer (CRC) and knockdown of Smad7 inhibits CRC cell growth, a phenomenon that associates with decreased expression of cell division cycle 25 homolog A and arrest of cells in the S phase of the cell cycle. These findings occur in CRC cells unresponsive to TGF-?1, thus suggesting the existence of a Smad7-mediated TGF-?1-independent mechanism that controls CRC cell behavior. Here we show that Smad7 inhibition with a specific Smad7 antisense oligonucleotide upregulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation, a transcription factor involved in the regulation of cell cycle arrest and induction of cell death, and induces activating transcription factor 4 (ATF4) and CCAAT/enhancer binding protein homology protein (CHOP), two downstream targets of eIF2?. Among the upstream kinases that control eIF2? phosphorylation, the serine?threonine protein kinase RNA (PKR), but not general control non-derepressible 2 (GCN2) and protein kinase RNA-like endoplasmic reticulum kinase (PERK), is activated by Smad7 knockdown. PKR silencing abolishes Smad7 antisense-induced eIF2? phosphorylation and ATF4/CHOP induction, thereby preventing Smad7 antisense-driven cell death. Smad7 inhibition diminishes interaction of PKR with protein kinase inhibitor p58 (p58IPK), a cellular inhibitor of PKR, but does not change the expression and/or activity of other factors involved in the control of PKR activation. These findings delineate a novel mechanism by which Smad7 knockdown promotes CRC cell death. �Smad7 knockdown activates protein kinase RNA-associated eIF2? pathway (epmc).pdf DeepDyve Pubget Overpricing