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Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies #MMPMID27078843
Gan Y; Wu J; Zhang S; Li L; Cao S; Mkandawire N; Ji K; Herath C; Gao C; Xu H; Zhou Y; Song X; Chen S; Chen Y; Yang T; Li J; Qiao Y; Hu S; Yin X; Lu Z
Oncotarget 2017[Mar]; 8 (12): 18699-711 PMID27078843show ga
A meta-analysis was performed to assess the association of coffee consumption with colorectal cancer and to investigate the shape of the association. Relevant prospective cohort studies were identified by a comprehensive search of the PubMed, Embase and Web of Science databases from their inception through August 2015. Either a random-effects model or fixed-effects model was used to compute the pooled risk estimates when appropriate. Linear and nonlinear dose-response meta-analyses were also performed. Nineteen prospective cohort studies involving 2,046,575 participants and 22,629 patients with colorectal cancer were included. The risk of colon cancer was decreased by 7% for every 4 cups per day of coffee (RR=0.93, 95%CI, 0.88-0.99; P=0.199). There was a threshold approximately five cups of coffee per day, and the inverse association for colorectal cancer appeared to be stronger at a higher range of intake. However, a nonlinear association of rectal cancer with coffee consumption was not observed (P for nonlinearity = 0.214). In conclusion, coffee consumption is significantly associated with a decreased risk of colorectal cancer at ? 5 cups per day of coffee consumption. The findings support the recommendations of including coffee as a healthy beverage for the prevention of colorectal cancer.