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10.7554/eLife.24722 http://scihub22266oqcxt.onion/10.7554/eLife.24722 C5400511!5400511!28355134     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28355134.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28355134|t=2017. The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors |pdf=|usr=}}{{28355134}} gab.com Text The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28355134 #FOAvip Genetic and environmental factors, such as metals, interact to determine neurological traits. We reasoned that interactomes of molecules handling metals in neurons should include novel metal homeostasis pathways. We focused on copper and its transporter ATP7A because ATP7A null mutations cause neurodegeneration. We performed ATP7A immunoaffinity chromatography and identified 541 proteins co-isolating with ATP7A. The ATP7A interactome concentrated gene products implicated in neurodegeneration and neurodevelopmental disorders, including subunits of the Golgi-localized conserved oligomeric Golgi (COG) complex. COG null cells possess altered content and subcellular localization of ATP7A and CTR1 (SLC31A1), the transporter required for copper uptake, as well as decreased total cellular copper, and impaired copper-dependent metabolic responses. Changes in the expression of ATP7A and COG subunits in Drosophila neurons altered synapse development in larvae and copper-induced mortality of adult flies. We conclude that the ATP7A interactome encompasses a novel COG-dependent mechanism to specify neuronal development and survival.DOI:http://dx.doi.org/10.7554/eLife.24722.001 Twit Text FOAVip The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28355134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28355134 #FOAvip English Wikipedia <ref>{{Cite pmid|28355134}}</ref> The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors #MMPMID28355134 Comstra HS; McArthy J; Rudin-Rush S; Hartwig C; Gokhale A; Zlatic SA; Blackburn JB; Werner E; Petris M; D?Souza P; Panuwet P; Barr DB; Lupashin V; Vrailas-Mortimer A; Faundez V eLife 2017[]; 6 (ä): ä PMID28355134show ga Genetic and environmental factors, such as metals, interact to determine neurological traits. We reasoned that interactomes of molecules handling metals in neurons should include novel metal homeostasis pathways. We focused on copper and its transporter ATP7A because ATP7A null mutations cause neurodegeneration. We performed ATP7A immunoaffinity chromatography and identified 541 proteins co-isolating with ATP7A. The ATP7A interactome concentrated gene products implicated in neurodegeneration and neurodevelopmental disorders, including subunits of the Golgi-localized conserved oligomeric Golgi (COG) complex. COG null cells possess altered content and subcellular localization of ATP7A and CTR1 (SLC31A1), the transporter required for copper uptake, as well as decreased total cellular copper, and impaired copper-dependent metabolic responses. Changes in the expression of ATP7A and COG subunits in Drosophila neurons altered synapse development in larvae and copper-induced mortality of adult flies. We conclude that the ATP7A interactome encompasses a novel COG-dependent mechanism to specify neuronal development and survival.DOI:http://dx.doi.org/10.7554/eLife.24722.001 äThe interactome of the copper transporter ATP7A belongs to a network o(epmc).pdf DeepDyve Pubget Overpricing