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10.1111/cas.13190 http://scihub22266oqcxt.onion/10.1111/cas.13190 C5406599!5406599!28182302     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28182302&cmd=llinks): Failed to open stream: HTTP request failed! 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Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation |pdf=|usr=}}{{28182302}} gab.com Text Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28182302 #FOAvip Malignant pleural mesothelioma (MPM) is characterized by dissemination and aggressive growth in the thoracic cavity. Podoplanin (PDPN) is an established diagnostic marker for MPM, but the function of PDPN in MPM is not fully understood. The purpose of this study was to determine the pathogenetic function of PDPN in MPM. Forty?seven of 52 tumors (90%) from Japanese patients with MPM and 3/6 (50%) MPM cell lines tested positive for PDPN. Knocking down PDPN in PDPN?high expressing MPM cells resulted in decreased cell motility. In contrast, overexpression of PDPN in PDPN?low expressing MPM cells enhanced cell motility. PDPN stimulated motility was mediated by activation of the RhoA/ROCK pathway. Moreover, knocking down PDPN with short hairpin (sh) RNA in PDPN?high expressing MPM cells resulted in decreased development of a thoracic tumor in mice with severe combined immune deficiency (SCID). In sharp contrast, transfection of PDPN in PDPN?low expressing MPM cells resulted in an increase in the number of Ki?67?positive proliferating tumor cells and it promoted progression of a thoracic tumor in SCID mice. Interestingly, PDPN promoted focus formation in vitro, and a low level of E?cadherin expression and YAP1 activation was observed in PDPN?high MPM tumors. These findings indicate that PDPN is a diagnostic marker as well as a pathogenetic regulator that promotes MPM progression by increasing cell motility and inducing focus formation. Therefore, PDPN might be a pathogenetic determinant of MPM dissemination and aggressive growth and may thus be an ideal therapeutic target. Twit Text FOAVip Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28182302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28182302 #FOAvip English Wikipedia <ref>{{Cite pmid|28182302}}</ref> Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation #MMPMID28182302 Takeuchi S; Fukuda K; Yamada T; Arai S; Takagi S; Ishii G; Ochiai A; Iwakiri S; Itoi K; Uehara H; Nishihara H; Fujita N; Yano S Cancer Sci 2017[Apr]; 108 (4): 696-703 PMID28182302show ga Malignant pleural mesothelioma (MPM) is characterized by dissemination and aggressive growth in the thoracic cavity. Podoplanin (PDPN) is an established diagnostic marker for MPM, but the function of PDPN in MPM is not fully understood. The purpose of this study was to determine the pathogenetic function of PDPN in MPM. Forty?seven of 52 tumors (90%) from Japanese patients with MPM and 3/6 (50%) MPM cell lines tested positive for PDPN. Knocking down PDPN in PDPN?high expressing MPM cells resulted in decreased cell motility. In contrast, overexpression of PDPN in PDPN?low expressing MPM cells enhanced cell motility. PDPN stimulated motility was mediated by activation of the RhoA/ROCK pathway. Moreover, knocking down PDPN with short hairpin (sh) RNA in PDPN?high expressing MPM cells resulted in decreased development of a thoracic tumor in mice with severe combined immune deficiency (SCID). In sharp contrast, transfection of PDPN in PDPN?low expressing MPM cells resulted in an increase in the number of Ki?67?positive proliferating tumor cells and it promoted progression of a thoracic tumor in SCID mice. Interestingly, PDPN promoted focus formation in vitro, and a low level of E?cadherin expression and YAP1 activation was observed in PDPN?high MPM tumors. These findings indicate that PDPN is a diagnostic marker as well as a pathogenetic regulator that promotes MPM progression by increasing cell motility and inducing focus formation. Therefore, PDPN might be a pathogenetic determinant of MPM dissemination and aggressive growth and may thus be an ideal therapeutic target. äPodoplanin promotes progression of malignant pleural mesothelioma by r(epmc).pdf DeepDyve Pubget Overpricing