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10.1161/CIRCIMAGING.116.005444

http://scihub22266oqcxt.onion/10.1161/CIRCIMAGING.116.005444
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C5408460!5408460!28351907
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suck abstract from ncbi


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pmid28351907      Circ+Cardiovasc+Imaging 2017 ; 10 (4): �
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  • Frequency, Predictors, and Implications of Abnormal Blood Pressure Responses During Dobutamine Stress Echocardiography #MMPMID28351907
  • Abram S; Arruda-Olson AM; Scott CG; Pellikka PA; Nkomo VT; Oh JK; Milan A; Abidian MM; McCully RB
  • Circ Cardiovasc Imaging 2017[Apr]; 10 (4): � PMID28351907show ga
  • Background: It is not known whether abnormal blood pressure (BP) responses during dobutamine stress echocardiography (DSE) are associated with abnormal test results, nor if such results indicate obstructive coronary artery disease (CAD). We sought to define the frequency of abnormal BP responses during DSE and their impact on accuracy of test results. Methods and Results: We studied 21,949 patients who underwent DSE at Mayo Clinic, Rochester MN, grouped by peak systolic BP achieved during the test. We also analyzed a subgroup who underwent coronary angiography within 30 days after positive DSE (n=1,126). The positive predictive value (PPV) of DSE was calculated for each BP subgroup. Patients with hypertensive response (n=1,905; 9%) were more likely to have positive DSE than those with normal (n=19,770; 90%) or hypotensive (n=274; 1%) BP responses (32% vs. 21% vs. 23% respectively, p<0.0001). Angiography, preformed in 1,126 patients, showed obstructive CAD (?50% stenosis) in 814 patients and severe CAD (?70% stenosis) in 708. PPV of DSE was similar for patients who had hypertensive and normal BP responses (69% vs. 73%, p=0.3), considering 50% stenosis cut-point. The proportion of severe CAD (?70% stenosis) was lower in patients who had hypertensive response compared to normal BP response (54% vs. 65%, p=0.005). Conclusions: Patients with hypertensive response during DSE are more likely to have stress-induced myocardial ischemia compared to those with normal or hypotensive BP responses, but are not more likely to have false positive DSE results. They are, however, less likely to have higher grade or multivessel CAD.



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