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10.1111/jdi.12587 http://scihub22266oqcxt.onion/10.1111/jdi.12587 C5415473!5415473!27868359     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27868359.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Diabetes+Investig 2017 ; 8 (3): 330-40 Nephropedia Template TP {{tp|p=27868359|t=2017. Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function |pdf=|usr=}}{{27868359}} gab.com Text Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function JO: J Diabetes Investig http://www.kidney.de/pget.php?&tw=1&pmid=27868359 #FOAvip Aims/Introduction: The present multicenter, prospective, controlled, open and randomized three?arm parallel study was designed to compare the effects of linagliptin with those of metformin on endothelial function. Materials and Methods: Type 2 diabetes patients treated with 750 mg of metformin (hemoglobin A1c ?6.0% and <8.0%, n = 96) were randomized to continue metformin 750 mg/day (control group, n = 29), metformin at 1,500 mg/day (metformin group, n = 26) and metformin 750 mg/day supplemented with linagliptin 5 mg/day (linagliptin add?on group, n = 29) and treated for 16 weeks. Vascular endothelial function was evaluated by flow?mediated dilation. The primary end?point was changes in flow?mediated dilation at 16 weeks relative to baseline. Results: Linagliptin significantly improved flow?mediated dilation from baseline (4.9 ± 2.7%) to 16 weeks (6.3 ± 2.7%, P < 0.05), whereas the other groups did not show any changes. Hemoglobin A1c at 16 weeks was significantly lower in the metformin and linagliptin add?on groups compared with the control (6.6 ± 0.6%, 6.5 ± 0.5% and 7.0 ± 0.6%, respectively). Single and multiple regression analyses showed that apolipoprotein B correlated significantly with change in flow?mediated dilation, and apolipoprotein B was decreased only in the linagliptin add?on group (?6.0 ± 11.3 mg/dL, P < 0.01). Conclusions: Linagliptin for 16 weeks improved endothelial function with a modest improvement in glycemic control. This effect was mediated, at least in part, by reduction in apolipoprotein B. Linagliptin has a protective role on endothelial function in patients with type 2 diabetes with moderate hyperglycemia. Twit Text FOAVip Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function ????J Diabetes Investig http://www.kidney.de/pget.php?&tw=1&pmid=27868359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27868359 #FOAvip English Wikipedia <ref>{{Cite pmid|27868359}}</ref> Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function #MMPMID27868359 Shigiyama F; Kumashiro N; Miyagi M; Iga R; Kobayashi Y; Kanda E; Uchino H; Hirose T J Diabetes Investig 2017[May]; 8 (3): 330-40 PMID27868359show ga Aims/Introduction: The present multicenter, prospective, controlled, open and randomized three?arm parallel study was designed to compare the effects of linagliptin with those of metformin on endothelial function. Materials and Methods: Type 2 diabetes patients treated with 750 mg of metformin (hemoglobin A1c ?6.0% and <8.0%, n = 96) were randomized to continue metformin 750 mg/day (control group, n = 29), metformin at 1,500 mg/day (metformin group, n = 26) and metformin 750 mg/day supplemented with linagliptin 5 mg/day (linagliptin add?on group, n = 29) and treated for 16 weeks. Vascular endothelial function was evaluated by flow?mediated dilation. The primary end?point was changes in flow?mediated dilation at 16 weeks relative to baseline. Results: Linagliptin significantly improved flow?mediated dilation from baseline (4.9 ± 2.7%) to 16 weeks (6.3 ± 2.7%, P < 0.05), whereas the other groups did not show any changes. Hemoglobin A1c at 16 weeks was significantly lower in the metformin and linagliptin add?on groups compared with the control (6.6 ± 0.6%, 6.5 ± 0.5% and 7.0 ± 0.6%, respectively). Single and multiple regression analyses showed that apolipoprotein B correlated significantly with change in flow?mediated dilation, and apolipoprotein B was decreased only in the linagliptin add?on group (?6.0 ± 11.3 mg/dL, P < 0.01). Conclusions: Linagliptin for 16 weeks improved endothelial function with a modest improvement in glycemic control. This effect was mediated, at least in part, by reduction in apolipoprotein B. Linagliptin has a protective role on endothelial function in patients with type 2 diabetes with moderate hyperglycemia. äLinagliptin improves endothelial function in patients with type 2 diab(epmc).pdf DeepDyve Pubget Overpricing