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10.3389/fonc.2017.00102 http://scihub22266oqcxt.onion/10.3389/fonc.2017.00102 C5439081!5439081!28589083     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28589083&cmd=llinks): Failed to open stream: HTTP request failed! 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The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression |pdf=|usr=}}{{28589083}} gab.com Text The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28589083 #FOAvip Mitochondria are dynamic organelles whose morphology and activity are extremely variable, depending on the metabolic state of the cell. In particular, their shape and movements within the cell are finely regulated by an increasing number of proteins, which take part in the process of mitochondrial fission/fusion and connect the organelles to the cytoskeleton. As to their activities, mitochondria are considered to be at the crossroad between cell life and death since, on the one hand, they are essential in ATP production and in multiple metabolic pathways but, on the other, they are involved in the intrinsic apoptotic cascade, triggered by different stress conditions. Importantly, the process of mitochondrial Ca2+ uptake, as well as the morphology and the dynamics of these organelles, is known to deeply impact on both pro-survival and pro-death mitochondrial activities. Recently, increasing evidence has accrued on a central role of deregulated mitochondrial functionalities in the onset and progression of different pathologies, ranging from neurodegenerative diseases to cancer. In this contribution, we will present the latest findings connecting alterations in the machineries that control mitochondrial dynamics and localization to specific cancer hallmarks, highlighting the importance of mitochondria for the viability of cancer cells and discussing their role as promising targets for the development of novel anticancer therapies. Twit Text FOAVip The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28589083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28589083 #FOAvip English Wikipedia <ref>{{Cite pmid|28589083}}</ref> The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression #MMPMID28589083 Pendin D; Filadi R; Pizzo P Front Oncol 2017[]; 7 (ä): ä PMID28589083show ga Mitochondria are dynamic organelles whose morphology and activity are extremely variable, depending on the metabolic state of the cell. In particular, their shape and movements within the cell are finely regulated by an increasing number of proteins, which take part in the process of mitochondrial fission/fusion and connect the organelles to the cytoskeleton. As to their activities, mitochondria are considered to be at the crossroad between cell life and death since, on the one hand, they are essential in ATP production and in multiple metabolic pathways but, on the other, they are involved in the intrinsic apoptotic cascade, triggered by different stress conditions. Importantly, the process of mitochondrial Ca2+ uptake, as well as the morphology and the dynamics of these organelles, is known to deeply impact on both pro-survival and pro-death mitochondrial activities. Recently, increasing evidence has accrued on a central role of deregulated mitochondrial functionalities in the onset and progression of different pathologies, ranging from neurodegenerative diseases to cancer. In this contribution, we will present the latest findings connecting alterations in the machineries that control mitochondrial dynamics and localization to specific cancer hallmarks, highlighting the importance of mitochondria for the viability of cancer cells and discussing their role as promising targets for the development of novel anticancer therapies. äThe Concerted Action of Mitochondrial Dynamics and Positioning: New Ch(epmc).pdf DeepDyve Pubget Overpricing