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10.1164/rccm.201608-1754OC http://scihub22266oqcxt.onion/10.1164/rccm.201608-1754OC C5440888!5440888!27805836     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27805836&cmd=llinks): Failed to open stream: HTTP request failed! 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Lumacaftor/Ivacaftor in Patients Aged 6?11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR |pdf=|usr=}}{{27805836}} gab.com Text Lumacaftor/Ivacaftor in Patients Aged 6 11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=27805836 #FOAvip Rationale: Combination lumacaftor/ivacaftor has been shown to improve lung function and other endpoints in patients aged 12 years and older with cystic fibrosis and homozygous for F508del-CFTR, but it has not been assessed in younger patients.Objectives: In this open-label phase III trial, we evaluated the safety, tolerability, pharmacodynamics, and efficacy of lumacaftor/ivacaftor combination therapy in patients aged 6?11 years with cystic fibrosis who were homozygous for F508del-CFTR.Methods: Patients (N?=?58) received 200 mg lumacaftor/250 mg ivacaftor orally every 12 hours for 24 weeks in addition to their existing cystic fibrosis medications.Measurements and Main Results: Lumacaftor/ivacaftor was well tolerated; the safety profile was generally similar to that observed in larger lumacaftor/ivacaftor trials with older patients. Four patients discontinued (two because of drug-related adverse events: elevated liver transaminases, n?=?1; rash, n?=?1). No safety concerns were associated with spirometry. No significant changes in percent predicted FEV1 were observed (change from baseline at Week 24, +2.5 percentage points; 95% confidence interval [CI], ?0.2 to 5.2; P?=?0.0671). At Week 24, significant improvements from baseline were observed in sweat chloride (?24.8 mmol/L; 95% CI, ?29.1 to ?20.5; P?<?0.0001), body mass index z score (+0.15; 95% CI, 0.08 to 0.22; P?<?0.0001), Cystic Fibrosis Questionnaire-Revised respiratory domain score (+5.4; 95% CI, 1.4 to 9.4; P?=?0.0085), and lung clearance index based on lung volume turnover required to reach 2.5% of starting N2 concentration (?0.88; 95% CI, ?1.40 to ?0.37; P?=?0.0018).Conclusions: Lumacaftor/ivacaftor was well tolerated in this young population; no new safety concerns were identified. Improvements in lung clearance index, sweat chloride, nutritional status, and health-related quality of life were observed after 24 weeks of treatment.Clinical trial registered with www.clinicaltrials.gov (NCT01897233). Twit Text FOAVip Lumacaftor/Ivacaftor in Patients Aged 6 11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=27805836 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27805836 #FOAvip English Wikipedia <ref>{{Cite pmid|27805836}}</ref> Lumacaftor/Ivacaftor in Patients Aged 6?11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR #MMPMID27805836 Milla CE; Ratjen F; Marigowda G; Liu F; Waltz D; Rosenfeld M Am J Respir Crit Care Med 2017[Apr]; 195 (7): 912-20 PMID27805836show ga Rationale: Combination lumacaftor/ivacaftor has been shown to improve lung function and other endpoints in patients aged 12 years and older with cystic fibrosis and homozygous for F508del-CFTR, but it has not been assessed in younger patients.Objectives: In this open-label phase III trial, we evaluated the safety, tolerability, pharmacodynamics, and efficacy of lumacaftor/ivacaftor combination therapy in patients aged 6?11 years with cystic fibrosis who were homozygous for F508del-CFTR.Methods: Patients (N?=?58) received 200 mg lumacaftor/250 mg ivacaftor orally every 12 hours for 24 weeks in addition to their existing cystic fibrosis medications.Measurements and Main Results: Lumacaftor/ivacaftor was well tolerated; the safety profile was generally similar to that observed in larger lumacaftor/ivacaftor trials with older patients. Four patients discontinued (two because of drug-related adverse events: elevated liver transaminases, n?=?1; rash, n?=?1). No safety concerns were associated with spirometry. No significant changes in percent predicted FEV1 were observed (change from baseline at Week 24, +2.5 percentage points; 95% confidence interval [CI], ?0.2 to 5.2; P?=?0.0671). At Week 24, significant improvements from baseline were observed in sweat chloride (?24.8 mmol/L; 95% CI, ?29.1 to ?20.5; P? �Lumacaftor/Ivacaftor in Patients Aged 6?11 Years with Cystic Fibrosis (epmc).pdf DeepDyve Pubget Overpricing