Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.5966/sctm.2016-0054 http://scihub22266oqcxt.onion/10.5966/sctm.2016-0054 C5442768!5442768!28297588     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28297588&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28297588.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Stem+Cells+Transl+Med 2017 ; 6 (3): 1006-17 Nephropedia Template TP {{tp|p=28297588|t=2017. Oncostatin M?Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin?Induced Pulmonary Fibrosis Through Paracrine Effects of the Hepatocyte Growth Factor |pdf=|usr=}}{{28297588}} gab.com Text Oncostatin M Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin Induced Pulmonary Fibrosis Through Paracrine Effects of the Hepatocyte Growth Factor JO: Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28297588 #FOAvip Mesenchymal stem cells (MSCs) are widely considered for treatment of pulmonary fibrosis based on the anti?inflammatory, antifibrotic, antiapoptotic, and regenerative properties of the cells. Recently, elevated levels of oncostatin M (OSM) have been reported in the bronchoalveolar lavage fluid of a pulmonary fibrosis animal model and in patients. In this work, we aimed to prolong engrafted MSC survival and to enhance the effectiveness of pulmonary fibrosis transplantation therapy by using OSM?preconditioned MSCs. OSM?preconditioned MSCs were shown to overexpress type 2 OSM receptor (gp130/OSMR?) and exhibited high susceptibility to OSM, resulting in upregulation of the paracrine factor, hepatocyte growth factor (HGF). Moreover, OSM?preconditioned MSCs enhanced cell proliferation and migration, attenuated transforming growth factor??1? or OSM?induced extracellular matrix production in MRC?5 fibroblasts through paracrine effects. In bleomycin?induced lung fibrotic mice, transplantation of OSM?preconditioned MSCs significantly improved pulmonary respiratory functions and downregulated expression of inflammatory factors and fibrotic factors in the lung tissues. Histopathologic examination indicated remarkable amelioration of the lung fibrosis. LacZ?tagged MSCs were detected in the lung tissues of the OSM?preconditioned MSC?treated mice 18 days after post?transplantation. Taken together, our data further demonstrated that HGF upregulation played an important role in mediating the therapeutic effects of transplanted OSM?preconditioned MSCs in alleviating lung fibrosis in the mice. Stem Cells Translational Medicine2017;6:1006?1017 Twit Text FOAVip Oncostatin M Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin Induced Pulmonary Fibrosis Through Paracrine Effects of the Hepatocyte Growth Factor ????Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28297588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28297588 #FOAvip English Wikipedia <ref>{{Cite pmid|28297588}}</ref> Oncostatin M?Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin?Induced Pulmonary Fibrosis Through Paracrine Effects of the Hepatocyte Growth Factor #MMPMID28297588 Lan Y; Theng S; Huang T; Choo K; Chen C; Kuo H; Chong K Stem Cells Transl Med 2017[Mar]; 6 (3): 1006-17 PMID28297588show ga Mesenchymal stem cells (MSCs) are widely considered for treatment of pulmonary fibrosis based on the anti?inflammatory, antifibrotic, antiapoptotic, and regenerative properties of the cells. Recently, elevated levels of oncostatin M (OSM) have been reported in the bronchoalveolar lavage fluid of a pulmonary fibrosis animal model and in patients. In this work, we aimed to prolong engrafted MSC survival and to enhance the effectiveness of pulmonary fibrosis transplantation therapy by using OSM?preconditioned MSCs. OSM?preconditioned MSCs were shown to overexpress type 2 OSM receptor (gp130/OSMR?) and exhibited high susceptibility to OSM, resulting in upregulation of the paracrine factor, hepatocyte growth factor (HGF). Moreover, OSM?preconditioned MSCs enhanced cell proliferation and migration, attenuated transforming growth factor??1? or OSM?induced extracellular matrix production in MRC?5 fibroblasts through paracrine effects. In bleomycin?induced lung fibrotic mice, transplantation of OSM?preconditioned MSCs significantly improved pulmonary respiratory functions and downregulated expression of inflammatory factors and fibrotic factors in the lung tissues. Histopathologic examination indicated remarkable amelioration of the lung fibrosis. LacZ?tagged MSCs were detected in the lung tissues of the OSM?preconditioned MSC?treated mice 18 days after post?transplantation. Taken together, our data further demonstrated that HGF upregulation played an important role in mediating the therapeutic effects of transplanted OSM?preconditioned MSCs in alleviating lung fibrosis in the mice. Stem Cells Translational Medicine2017;6:1006?1017 �Oncostatin M?Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin(epmc).pdf DeepDyve Pubget Overpricing