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10.1086/689289 http://scihub22266oqcxt.onion/10.1086/689289 C5448548!5448548!28680568     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28680568&cmd=llinks): Failed to open stream: HTTP request failed! 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Combined oral administration of L-arginine and tetrahydrobiopterin in a rat model of pulmonary arterial hypertension |pdf=|usr=}}{{28680568}} gab.com Text Combined oral administration of L-arginine and tetrahydrobiopterin in a rat model of pulmonary arterial hypertension JO: Pulm Circ http://www.kidney.de/pget.php?&tw=1&pmid=28680568 #FOAvip Alterations in the nitric oxide (NO) pathway play a major role in pulmonary arterial hypertension (PAH). L-arginine (LA) and tetrahydrobiopterin (BH4) are main substrates in the production of NO, which mediates pulmonary vasodilation. Administration of either LA or BH4 decrease pulmonary artery pressure (PAP). A combined administration of both may have synergistic effects in the therapy of PAH. In a telemetrically monitored model of unilateral pneumonectomy and monocrotaline-induced PAH, male Sprague-Dawley rats received either LA (300?mg/kg; n?=?15), BH4 (20?mg/kg; n?=?15), the combination of LA and BH4 (300?mg/kg, 20?mg/kg; n?=?15), or vehicle (control group; n?=?10) from day 28 after monocrotaline induction. Therapy was orally administered once daily over consecutive 14 days. LA, BH4, or both equally lowered PAP, increased pulmonary vascular elasticity, restored spontaneous locomotoric activity, prevented body weight loss and palliated small vessel disease of severely pulmonary hypertensive rats. BH4 substitution lowered asymmetric dimethylarginine levels sustainably at 60?min after administration and downregulated endothelial NO synthase mRNA expression. No significant survival, macro- and histomorphologic or hemodynamic differences were found between therapy groups at the end of the study period. Administration of LA and BH4 both mediated a decrease of mean PAP, attenuated right ventricular hypertrophy and small vessel disease in monocrotaline-induced pulmonary hypertensive rats, though a combined administration of both substances did not reveal any synergistic therapy effects in our animal model. Twit Text FOAVip Combined oral administration of L-arginine and tetrahydrobiopterin in a rat model of pulmonary arterial hypertension ????Pulm Circ http://www.kidney.de/pget.php?&tw=1&pmid=28680568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28680568 #FOAvip English Wikipedia <ref>{{Cite pmid|28680568}}</ref> Combined oral administration of L-arginine and tetrahydrobiopterin in a rat model of pulmonary arterial hypertension #MMPMID28680568 Schreiber C; Eilenberg M; Panzenboeck A; Winter M; Bergmeister H; Herzog R; Mascherbauer J; Lang I; Bonderman D Pulm Circ 2017[Mar]; 7 (1): 89-97 PMID28680568show ga Alterations in the nitric oxide (NO) pathway play a major role in pulmonary arterial hypertension (PAH). L-arginine (LA) and tetrahydrobiopterin (BH4) are main substrates in the production of NO, which mediates pulmonary vasodilation. Administration of either LA or BH4 decrease pulmonary artery pressure (PAP). A combined administration of both may have synergistic effects in the therapy of PAH. In a telemetrically monitored model of unilateral pneumonectomy and monocrotaline-induced PAH, male Sprague-Dawley rats received either LA (300?mg/kg; n?=?15), BH4 (20?mg/kg; n?=?15), the combination of LA and BH4 (300?mg/kg, 20?mg/kg; n?=?15), or vehicle (control group; n?=?10) from day 28 after monocrotaline induction. Therapy was orally administered once daily over consecutive 14 days. LA, BH4, or both equally lowered PAP, increased pulmonary vascular elasticity, restored spontaneous locomotoric activity, prevented body weight loss and palliated small vessel disease of severely pulmonary hypertensive rats. BH4 substitution lowered asymmetric dimethylarginine levels sustainably at 60?min after administration and downregulated endothelial NO synthase mRNA expression. No significant survival, macro- and histomorphologic or hemodynamic differences were found between therapy groups at the end of the study period. Administration of LA and BH4 both mediated a decrease of mean PAP, attenuated right ventricular hypertrophy and small vessel disease in monocrotaline-induced pulmonary hypertensive rats, though a combined administration of both substances did not reveal any synergistic therapy effects in our animal model. äCombined oral administration of L-arginine and tetrahydrobiopterin in (epmc).pdf DeepDyve Pubget Overpricing