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10.1371/journal.pone.0178018

http://scihub22266oqcxt.onion/10.1371/journal.pone.0178018
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C5451026!5451026!28562629
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suck abstract from ncbi


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pmid28562629      PLoS+One 2017 ; 12 (5): ä
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  • A retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy #MMPMID28562629
  • Miyawaki Y; Katsuyama T; Sada KE; Hiramatsu S; Ohashi K; Morishita M; Katsuyama E; Watanabe H; Takano-Narazaki M; Toyota-Tatebe N; Sunahori-Watanabe K; Kawabata T; Inoue T; Kinomura M; Sugiyama H; Wada J
  • PLoS One 2017[]; 12 (5): ä PMID28562629show ga
  • Aims: To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN) and to confirm the risk factors for the development of GC-DM. Methods: The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up. Results: During hospitalization, 19 of the 95 patients developed GC-DM (20.0%), and the patients with GC-DM were significantly older and had a higher rate of family history of diabetes and higher HbA1c levels. The prevalence of hypertension was higher and the eGFR was numerically lower in patients with GC-DM than in those without. Older age (?45 years) and a family history of diabetes emerged as independent risk factors for the development of GC-DM (odds ratio [OR], 6.3 and 95% confidence interval [CI], 1.6?27.6; OR, 4.4 and 95% CI, 1.2?16.6, respectively). No patients were newly diagnosed with GC-DM during 1-year observation period at out-patient clinic. Conclusions: Among the patients with IgAN, 20% developed GC-DM during the hospitalization period, confirming the family history of diabetes is clinically necessary before starting GC therapy.
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