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10.3390/ijms18050855 http://scihub22266oqcxt.onion/10.3390/ijms18050855 C5454808!5454808!28448446     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28448446&cmd=llinks): Failed to open stream: HTTP request failed! 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Renalase Protects against Renal Fibrosis by Inhibiting the Activation of the ERK Signaling Pathways |pdf=|usr=}}{{28448446}} gab.com Text Renalase Protects against Renal Fibrosis by Inhibiting the Activation of the ERK Signaling Pathways JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28448446 #FOAvip Renal interstitial fibrosis is a common pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease. Renalase, acting as a signaling molecule, has been reported to have cardiovascular and renal protective effects. However, its role in renal fibrosis remains unknown. In this study, we evaluated the therapeutic efficacy of renalase in rats with complete unilateral ureteral obstruction (UUO) and examined the inhibitory effects of renalase on transforming growth factor-?1 (TGF-?1)-induced epithelial?mesenchymal transition (EMT) in human proximal renal tubular epithelial (HK-2) cells. We found that in the UUO model, the expression of renalase was markedly downregulated and adenoviral-mediated expression of renalase significantly attenuated renal interstitial fibrosis, as evidenced by the maintenance of E-cadherin expression and suppressed expression of ?-smooth muscle actin (?-SMA), fibronectin and collagen-I. In vitro, renalase inhibited TGF-?1-mediated upregulation of ?-SMA and downregulation of E-cadherin. Increased levels of Phospho-extracellular regulated protein kinases (p-ERK1/2) in TGF-?1-stimulated cells were reversed by renalase cotreatment. When ERK1 was overexpressed, the inhibition of TGF-?1-induced EMT and fibrosis mediated by renalase was attenuated. Our study provides the first evidence that renalase can ameliorate renal interstitial fibrosis by suppression of tubular EMT through inhibition of the ERK pathway. These results suggest that renalase has potential renoprotective effects in renal interstitial fibrosis and may be an effective agent for slowing CKD progression. Twit Text FOAVip Renalase Protects against Renal Fibrosis by Inhibiting the Activation of the ERK Signaling Pathways ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28448446 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28448446 #FOAvip English Wikipedia <ref>{{Cite pmid|28448446}}</ref> Renalase Protects against Renal Fibrosis by Inhibiting the Activation of the ERK Signaling Pathways #MMPMID28448446 Wu Y; Wang L; Deng D; Zhang Q; Liu W Int J Mol Sci 2017[May]; 18 (5): ä PMID28448446show ga Renal interstitial fibrosis is a common pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease. Renalase, acting as a signaling molecule, has been reported to have cardiovascular and renal protective effects. However, its role in renal fibrosis remains unknown. In this study, we evaluated the therapeutic efficacy of renalase in rats with complete unilateral ureteral obstruction (UUO) and examined the inhibitory effects of renalase on transforming growth factor-?1 (TGF-?1)-induced epithelial?mesenchymal transition (EMT) in human proximal renal tubular epithelial (HK-2) cells. We found that in the UUO model, the expression of renalase was markedly downregulated and adenoviral-mediated expression of renalase significantly attenuated renal interstitial fibrosis, as evidenced by the maintenance of E-cadherin expression and suppressed expression of ?-smooth muscle actin (?-SMA), fibronectin and collagen-I. In vitro, renalase inhibited TGF-?1-mediated upregulation of ?-SMA and downregulation of E-cadherin. Increased levels of Phospho-extracellular regulated protein kinases (p-ERK1/2) in TGF-?1-stimulated cells were reversed by renalase cotreatment. When ERK1 was overexpressed, the inhibition of TGF-?1-induced EMT and fibrosis mediated by renalase was attenuated. Our study provides the first evidence that renalase can ameliorate renal interstitial fibrosis by suppression of tubular EMT through inhibition of the ERK pathway. These results suggest that renalase has potential renoprotective effects in renal interstitial fibrosis and may be an effective agent for slowing CKD progression. äRenalase Protects against Renal Fibrosis by Inhibiting the Activation (epmc).pdf DeepDyve Pubget Overpricing