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10.1210/jc.2016-4038 http://scihub22266oqcxt.onion/10.1210/jc.2016-4038 C5460726!5460726!28323960     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28323960&cmd=llinks): Failed to open stream: HTTP request failed! 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FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls |pdf=|usr=}}{{28323960}} gab.com Text FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls JO: J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28323960 #FOAvip Context:: Fibroblast growth factor (FGF)23 is a critical determinant of phosphate homeostasis. The role of FGF23, however, in regulating physiologic changes in serum phosphate and renal phosphate handling across childhood is not well described. In addition, animal models have suggested a role for FGF23 in regulating renal calcium excretion. Objective:: To assess changes in FGF23 concentrations across childhood in relation to changes in mineral ions and hormones of mineral ion homeostasis. Design:: This was a cross-sectional study. Setting:: The study was conducted at a Clinical Research Center at a tertiary care hospital. Patients or Other Participants:: Ninety healthy girls ages 9 to 18 years were recruited from the surrounding community. Main Outcome Measures:: The associations of intact and C-terminal FGF23 concentrations with measures of mineral ion homeostasis were determined by univariable and multivariable linear regression. Results:: Serum phosphate and renal phosphate excretion varied with age, as expected (R = ?0.49, P < 0.001 and R = ?0.48, P < 0.001, respectively). Neither intact nor C-terminal FGF23 varied with age, and FGF23 was not correlated with serum or urinary phosphate. Intact FGF23 was positively correlated with serum calcium (R = 0.39, P < 0.001) and negatively correlated with urinary calcium/creatinine ratio (R = ?0.27, P = 0.011). Conclusions:: The changes in serum and urinary phosphate handling across childhood do not appear to be determined by alterations in FGF23 concentrations. These data may point to a role for FGF23 in calcium regulation in human physiology. Twit Text FOAVip FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls ????J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28323960 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28323960 #FOAvip English Wikipedia <ref>{{Cite pmid|28323960}}</ref> FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls #MMPMID28323960 Mitchell DM; J�ppner H; Burnett-Bowie SAM J Clin Endocrinol Metab 2017[Apr]; 102 (4): 1151-60 PMID28323960show ga Context:: Fibroblast growth factor (FGF)23 is a critical determinant of phosphate homeostasis. The role of FGF23, however, in regulating physiologic changes in serum phosphate and renal phosphate handling across childhood is not well described. In addition, animal models have suggested a role for FGF23 in regulating renal calcium excretion. Objective:: To assess changes in FGF23 concentrations across childhood in relation to changes in mineral ions and hormones of mineral ion homeostasis. Design:: This was a cross-sectional study. Setting:: The study was conducted at a Clinical Research Center at a tertiary care hospital. Patients or Other Participants:: Ninety healthy girls ages 9 to 18 years were recruited from the surrounding community. Main Outcome Measures:: The associations of intact and C-terminal FGF23 concentrations with measures of mineral ion homeostasis were determined by univariable and multivariable linear regression. Results:: Serum phosphate and renal phosphate excretion varied with age, as expected (R = ?0.49, P < 0.001 and R = ?0.48, P < 0.001, respectively). Neither intact nor C-terminal FGF23 varied with age, and FGF23 was not correlated with serum or urinary phosphate. Intact FGF23 was positively correlated with serum calcium (R = 0.39, P < 0.001) and negatively correlated with urinary calcium/creatinine ratio (R = ?0.27, P = 0.011). Conclusions:: The changes in serum and urinary phosphate handling across childhood do not appear to be determined by alterations in FGF23 concentrations. These data may point to a role for FGF23 in calcium regulation in human physiology. �FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enh(epmc).pdf DeepDyve Pubget Overpricing