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10.1111/cei.12957 http://scihub22266oqcxt.onion/10.1111/cei.12957 C5461103!5461103!28257596     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28257596&cmd=llinks): Failed to open stream: HTTP request failed! 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Interferon?? coincides with suppressed levels of pentraxin?3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro |pdf=|usr=}}{{28257596}} gab.com Text Interferon coincides with suppressed levels of pentraxin 3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28257596 #FOAvip Dysfunctional elimination of cell debris, and the role of opsonins such as pentraxins, is of interest regarding systemic lupus erythematosus (SLE) pathogenesis. Interferon (IFN)?? is typically elevated during SLE flares, and inhibits hepatocyte production of the pentraxin ?C?reactive protein? (CRP), partly explaining the poor correlation between CRP levels and SLE disease activity. The extrahepatically produced ?pentraxin 3? (PTX3) shares waste disposal functions with CRP, but has not been studied extensively in SLE. We analysed serum PTX3 in SLE, and assessed its interference with IFN?? in vitro. Serum samples from 243 patients with SLE and 100 blood donors were analysed regarding PTX3. Patient sera were analysed for IFN??, and genotyped for three PTX3 single nucleotide polymorphisms reported previously to associate with PTX3 levels. Stimulated PTX3 release was assessed in the presence or absence of IFN?? in blood donor neutrophils and peripheral blood mononuclear cells (PBMC). Serum PTX3 was 44% lower in patients with SLE compared to blood donors (P?<?0·0001) and correlated with leucocyte variables. Patients with undetectable IFN?? had 29% higher median PTX3 level than patients with detectable IFN?? (P?=?0·01). PTX3 production by PBMC was inhibited by IFN??, whereas neutrophil degranulation of PTX3 was increased. No differences in PTX3 levels were observed between the SNPs. In conclusion, median serum PTX3 is lower in SLE (especially when IFN?? is detectable) compared to blood donors. In addition to its potential consumption during waste disposal, it is plausible that IFN?? also attenuates PTX3 by inhibiting synthesis by PBMC and/or exhausting PTX3 storage in neutrophil granules. Twit Text FOAVip Interferon coincides with suppressed levels of pentraxin 3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28257596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28257596 #FOAvip English Wikipedia <ref>{{Cite pmid|28257596}}</ref> Interferon?? coincides with suppressed levels of pentraxin?3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro #MMPMID28257596 Wirestam L; Enocsson H; Skogh T; Eloranta ML; Rönnblom L; Sjöwall C; Wetterö J Clin Exp Immunol 2017[Jul]; 189 (1): 83-91 PMID28257596show ga Dysfunctional elimination of cell debris, and the role of opsonins such as pentraxins, is of interest regarding systemic lupus erythematosus (SLE) pathogenesis. Interferon (IFN)?? is typically elevated during SLE flares, and inhibits hepatocyte production of the pentraxin ?C?reactive protein? (CRP), partly explaining the poor correlation between CRP levels and SLE disease activity. The extrahepatically produced ?pentraxin 3? (PTX3) shares waste disposal functions with CRP, but has not been studied extensively in SLE. We analysed serum PTX3 in SLE, and assessed its interference with IFN?? in vitro. Serum samples from 243 patients with SLE and 100 blood donors were analysed regarding PTX3. Patient sera were analysed for IFN??, and genotyped for three PTX3 single nucleotide polymorphisms reported previously to associate with PTX3 levels. Stimulated PTX3 release was assessed in the presence or absence of IFN?? in blood donor neutrophils and peripheral blood mononuclear cells (PBMC). Serum PTX3 was 44% lower in patients with SLE compared to blood donors (P? äInterferon?? coincides with suppressed levels of pentraxin?3 (PTX3) in(epmc).pdf DeepDyve Pubget Overpricing