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10.1371/journal.pone.0179222 http://scihub22266oqcxt.onion/10.1371/journal.pone.0179222 C5464612!5464612!28594913     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28594913&cmd=llinks): Failed to open stream: HTTP request failed! 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Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil |pdf=|usr=}}{{28594913}} gab.com Text Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28594913 #FOAvip Few studies have reported the effect of 10-valent pneumococcal conjugate vaccine (PCV10) on otitis media (OM) in infants. In particular, no population-based study in upper-middle income countries is available. In 2010, Brazil introduced PCV10 into its routine National Immunization Program using a 3+1 schedule. We measured the impact of PCV10 on all-cause OM in children. An interrupted time-series analysis was conducted in Goiânia/Brazil considering monthly rates (per 100,000) of all-cause OM outpatient visits in children aged 2?23 months. We used case-based data from the Outpatient Visits Information System of the Unified Health System coded for ICD-10 diagnosis for the period of August/2008 to July/2015. As a comparator, we used rates of outpatient visits due to all-other causes. The relative reduction of all-cause OM and all-other causes of outpatient visits were calculated as the difference between the predicted and observed cumulative rates of the PCV10 post-vaccination period. We then subtracted the relative reduction of all-other causes of outpatient visits from all-cause OM to obtain the impact of PCV10 on OM. In total, 6,401 OM outpatient visits were recorded in 4,793 children aged 2?23 months. Of these, 922 (19.2%) children had more than one OM episode. A significant reduction in all-cause OM visits was observed (50.7%; 95%CI: 42.2?59.2%; p = 0.013), while the reduction in visits due to all-other causes was 7.7% (95% CI 0.8?14.7%; p<0.001). The impact of PCV10 on all-cause OM was thus estimated at 43.0% (95%CI 41.4?44.5). This is the first study to show significant PCV10 impact on OM outpatient visits in infants in a developing country. Our findings corroborate the available evidence from developed countries. Twit Text FOAVip Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28594913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28594913 #FOAvip English Wikipedia <ref>{{Cite pmid|28594913}}</ref> Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil #MMPMID28594913 Sartori AL; Minamisava R; Bierrenbach AL; Toscano CM; Afonso ET; Morais-Neto OL; Antunes JLF; Cristo EB; Andrade AL PLoS One 2017[]; 12 (6): ä PMID28594913show ga Few studies have reported the effect of 10-valent pneumococcal conjugate vaccine (PCV10) on otitis media (OM) in infants. In particular, no population-based study in upper-middle income countries is available. In 2010, Brazil introduced PCV10 into its routine National Immunization Program using a 3+1 schedule. We measured the impact of PCV10 on all-cause OM in children. An interrupted time-series analysis was conducted in Goiânia/Brazil considering monthly rates (per 100,000) of all-cause OM outpatient visits in children aged 2?23 months. We used case-based data from the Outpatient Visits Information System of the Unified Health System coded for ICD-10 diagnosis for the period of August/2008 to July/2015. As a comparator, we used rates of outpatient visits due to all-other causes. The relative reduction of all-cause OM and all-other causes of outpatient visits were calculated as the difference between the predicted and observed cumulative rates of the PCV10 post-vaccination period. We then subtracted the relative reduction of all-other causes of outpatient visits from all-cause OM to obtain the impact of PCV10 on OM. In total, 6,401 OM outpatient visits were recorded in 4,793 children aged 2?23 months. Of these, 922 (19.2%) children had more than one OM episode. A significant reduction in all-cause OM visits was observed (50.7%; 95%CI: 42.2?59.2%; p = 0.013), while the reduction in visits due to all-other causes was 7.7% (95% CI 0.8?14.7%; p<0.001). The impact of PCV10 on all-cause OM was thus estimated at 43.0% (95%CI 41.4?44.5). This is the first study to show significant PCV10 impact on OM outpatient visits in infants in a developing country. Our findings corroborate the available evidence from developed countries. äReduction in all-cause otitis media-related outpatient visits in child(epmc).pdf DeepDyve Pubget Overpricing