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10.1038/s41598-017-02358-z http://scihub22266oqcxt.onion/10.1038/s41598-017-02358-z C5471256!5471256!28615628     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28615628&cmd=llinks): Failed to open stream: HTTP request failed! 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Glucocorticoids ameliorate TGF-?1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways |pdf=|usr=}}{{28615628}} gab.com Text Glucocorticoids ameliorate TGF- 1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28615628 #FOAvip Chronic rhinosinusitis with nasal polyps (CRSwNP) is closely associated with tissue remodeling. Epithelial-to-mesenchymal transition (EMT), a process of tissue remodeling, can be a therapeutic target of CRSwNP. Glucocorticoids are a type of steroid hormone that is used primarily in medical therapy for patients with CRSwNP; however, their effects on EMT in the airway epithelium remain unknown. To investigate the effects of dexamethasone and fluticasone propionate, a class of glucocorticoids, on transforming growth factor-?1 (TGF-?1) -induced EMT, we used A549 cells, human primary nasal epithelial cells (hPNECs) and ex vivo organ culture of the inferior turbinate. TGF-?1 induced changes in cell morphology, suppressed the expression of E-cadherin and enhanced the expression of a-smooth muscle actin, vimentin and fibronectin in A549 cells. However, glucocorticoids inhibited EMT, migration and invasion enhancement by TGF-?1. We found that the induction of phosphorylated ERK, p38 and the activity of Snail and Slug transcription factors by TGF-?1 were suppressed by glucocorticoids. Glucocorticoids also had a similar effect in hPNECs and ex vivo organ cultures of the inferior turbinate. These findings suggest that glucocorticoids might be a useful therapy for preventing tissue remodeling by blocking the EMT initiated by TGF-?1-induced MAPK and Snail/Slug signaling pathways in CRSwNP. Twit Text FOAVip Glucocorticoids ameliorate TGF- 1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28615628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28615628 #FOAvip English Wikipedia <ref>{{Cite pmid|28615628}}</ref> Glucocorticoids ameliorate TGF-?1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways #MMPMID28615628 Yang HW; Lee SA; Shin JM; Park IH; Lee HM Sci Rep 2017[]; 7 (ä): ä PMID28615628show ga Chronic rhinosinusitis with nasal polyps (CRSwNP) is closely associated with tissue remodeling. Epithelial-to-mesenchymal transition (EMT), a process of tissue remodeling, can be a therapeutic target of CRSwNP. Glucocorticoids are a type of steroid hormone that is used primarily in medical therapy for patients with CRSwNP; however, their effects on EMT in the airway epithelium remain unknown. To investigate the effects of dexamethasone and fluticasone propionate, a class of glucocorticoids, on transforming growth factor-?1 (TGF-?1) -induced EMT, we used A549 cells, human primary nasal epithelial cells (hPNECs) and ex vivo organ culture of the inferior turbinate. TGF-?1 induced changes in cell morphology, suppressed the expression of E-cadherin and enhanced the expression of a-smooth muscle actin, vimentin and fibronectin in A549 cells. However, glucocorticoids inhibited EMT, migration and invasion enhancement by TGF-?1. We found that the induction of phosphorylated ERK, p38 and the activity of Snail and Slug transcription factors by TGF-?1 were suppressed by glucocorticoids. Glucocorticoids also had a similar effect in hPNECs and ex vivo organ cultures of the inferior turbinate. These findings suggest that glucocorticoids might be a useful therapy for preventing tissue remodeling by blocking the EMT initiated by TGF-?1-induced MAPK and Snail/Slug signaling pathways in CRSwNP. äGlucocorticoids ameliorate TGF-?1-mediated epithelial-to-mesenchymal t(epmc).pdf DeepDyve Pubget Overpricing