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10.1093/ndtplus/sfq012 http://scihub22266oqcxt.onion/10.1093/ndtplus/sfq012 C5477947!5477947!28657046     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28657046&cmd=llinks): Failed to open stream: HTTP request failed! 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Simvastatin-induced myoglobinuric acute kidney injury following ciclosporin treatment for alopecia universalis |pdf=|usr=}}{{28657046}} gab.com Text Simvastatin-induced myoglobinuric acute kidney injury following ciclosporin treatment for alopecia universalis JO: NDT Plus http://www.kidney.de/pget.php?&tw=1&pmid=28657046 #FOAvip Alopecia areata can affect the entire scalp (alopecia totalis) or cause loss of all body hair (alopecia universalis). Ciclosporin (CsA) has been suggested for its treatment, with controversial results. Concomitant use of statins and CsA may increase the risk of rhabdomyolysis due to drug?drug interactions.Here we report the case of a 45-year-old woman treated with CsA for alopecia universalis, who presented a severe myoglobinuric acute kidney injury following the concomitant use of simvastatin. Upon admission to our unit, she was oligo-anuric. Her serum creatinine level was 13.8 mg/dl. CsA and simvastatin therapy were stopped, and haemodialysis treatment was started (eight daily dialysis sessions) until sufficient kidney function was regained. After 1 month, her serum creatinine level was 3.5 mg/dl; after 2 months and onwards (follow-up of 4 months), her serum creatinine level was 1.4 mg/dl and creatinine clearance was 43.2 ml/min.In conclusion, physicians should be aware of the potential risks of the combined use of CsA and statins. Patients should be advised to report any muscle symptoms when they are on statins and CsA. The laboratory follow-up should include the monitoring of serum creatinine and muscle enzyme levels, blood CsA levels and liver function tests. Twit Text FOAVip Simvastatin-induced myoglobinuric acute kidney injury following ciclosporin treatment for alopecia universalis ????NDT Plus http://www.kidney.de/pget.php?&tw=1&pmid=28657046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28657046 #FOAvip English Wikipedia <ref>{{Cite pmid|28657046}}</ref> Simvastatin-induced myoglobinuric acute kidney injury following ciclosporin treatment for alopecia universalis #MMPMID28657046 Teutonico A; Libutti P; Lomonte C; Basile C NDT Plus 2010[Jun]; 3 (3): 273-5 PMID28657046show ga Alopecia areata can affect the entire scalp (alopecia totalis) or cause loss of all body hair (alopecia universalis). Ciclosporin (CsA) has been suggested for its treatment, with controversial results. Concomitant use of statins and CsA may increase the risk of rhabdomyolysis due to drug?drug interactions.Here we report the case of a 45-year-old woman treated with CsA for alopecia universalis, who presented a severe myoglobinuric acute kidney injury following the concomitant use of simvastatin. Upon admission to our unit, she was oligo-anuric. Her serum creatinine level was 13.8 mg/dl. CsA and simvastatin therapy were stopped, and haemodialysis treatment was started (eight daily dialysis sessions) until sufficient kidney function was regained. After 1 month, her serum creatinine level was 3.5 mg/dl; after 2 months and onwards (follow-up of 4 months), her serum creatinine level was 1.4 mg/dl and creatinine clearance was 43.2 ml/min.In conclusion, physicians should be aware of the potential risks of the combined use of CsA and statins. Patients should be advised to report any muscle symptoms when they are on statins and CsA. The laboratory follow-up should include the monitoring of serum creatinine and muscle enzyme levels, blood CsA levels and liver function tests. �Simvastatin-induced myoglobinuric acute kidney injury following ciclos(epmc).pdf DeepDyve Pubget Overpricing