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10.1038/s41598-017-04286-4 http://scihub22266oqcxt.onion/10.1038/s41598-017-04286-4 C5491527!5491527!28663562     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28663562&cmd=llinks): Failed to open stream: HTTP request failed! 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Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer |pdf=|usr=}}{{28663562}} gab.com Text Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28663562 #FOAvip Inflammasomes are multi-proteins complex regulating inflammation-associated signaling. While inflammation plays a critical role in cancer cell growth, studies remain uncharacterized on the role of inflammasomes in prostate cancer. Using Gene Expression Omnibus (GEO) public datasets, we screened the expression profiles of inflammasome sensors NLRP3, NLRC4, NLRP6, NRLP12, and AIM2 in prostate tumor tissues, and verified their mRNA level in a panel of prostate cancer cell lines. The selected expression of NLRP3 and NLRP12 inflammasomes was validated, and the clinical association was evaluated in human prostate archival tumor tissues. We observed that the expression of inflammasome sensors was dysregulated at the mRNA level except for the NLRP12. The intensity of NLRP12 immunostaining was significantly higher in malignant prostate as compared to their adjacent benign tissues. In contrast, the NLRP3 immunostaining in prostate tissues was heterogeneous. The inflammasome complex proteins ASC (apoptosis-associated speck-like protein containing a CARD) and pro-caspase-1, as well as its downstream targets IL-1? and IL-18 were confined to aggressive prostate cancer cells. These data suggest an increased expression of NLRP12 in association with prostate cancer and support the role of NLRP12 inflammasome complex regulating inflammatory cytokines in understanding the role of inflammation in the prostate cancer. Twit Text FOAVip Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28663562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28663562 #FOAvip English Wikipedia <ref>{{Cite pmid|28663562}}</ref> Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer #MMPMID28663562 Karan D; Tawfik O; Dubey S Sci Rep 2017[]; 7 (ä): ä PMID28663562show ga Inflammasomes are multi-proteins complex regulating inflammation-associated signaling. While inflammation plays a critical role in cancer cell growth, studies remain uncharacterized on the role of inflammasomes in prostate cancer. Using Gene Expression Omnibus (GEO) public datasets, we screened the expression profiles of inflammasome sensors NLRP3, NLRC4, NLRP6, NRLP12, and AIM2 in prostate tumor tissues, and verified their mRNA level in a panel of prostate cancer cell lines. The selected expression of NLRP3 and NLRP12 inflammasomes was validated, and the clinical association was evaluated in human prostate archival tumor tissues. We observed that the expression of inflammasome sensors was dysregulated at the mRNA level except for the NLRP12. The intensity of NLRP12 immunostaining was significantly higher in malignant prostate as compared to their adjacent benign tissues. In contrast, the NLRP3 immunostaining in prostate tissues was heterogeneous. The inflammasome complex proteins ASC (apoptosis-associated speck-like protein containing a CARD) and pro-caspase-1, as well as its downstream targets IL-1? and IL-18 were confined to aggressive prostate cancer cells. These data suggest an increased expression of NLRP12 in association with prostate cancer and support the role of NLRP12 inflammasome complex regulating inflammatory cytokines in understanding the role of inflammation in the prostate cancer. äExpression analysis of inflammasome sensors and implication of NLRP12 (epmc).pdf DeepDyve Pubget Overpricing