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10.2169/internalmedicine.56.8142

http://scihub22266oqcxt.onion/10.2169/internalmedicine.56.8142
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C5498204!5498204!28566603
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suck abstract from ncbi


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pmid28566603      Intern+Med 2017 ; 56 (11): 1387-91
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  • Febuxostat for the Prevention of Recurrent 2,8-dihydroxyadenine Nephropathy due to Adenine Phosphoribosyltransferase Deficiency Following Kidney Transplantation #MMPMID28566603
  • Nanmoku K; Kurosawa A; Shinzato T; Shimizu T; Kimura T; Yagisawa T
  • Intern Med 2017[Jun]; 56 (11): 1387-91 PMID28566603show ga
  • Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder that results in irreversible renal damage due to 2,8-dihydroxyadenine (DHA) nephropathy. A 28-year-old man underwent living-related kidney transplantation for chronic kidney disease of unknown etiology. Numerous spherical brownish crystals observed in his urinary sediment on postoperative day 3 and were observed within the tubular lumen of renal allograft biopsy specimens on postoperative day 7. After a genetic diagnosis, febuxostat treatment was started on postoperative day 7, with the dosage gradually increased to 80 mg/day until complete the disappearance of 2,8-DHA crystals. Febuxostat prevented secondary 2,8-DHA nephropathy after kidney transplantation.
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