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10.1097/MD.0000000000007484 http://scihub22266oqcxt.onion/10.1097/MD.0000000000007484 C5502193!5502193!28682920     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28682920&cmd=llinks): Failed to open stream: HTTP request failed! 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The diagnostic accuracy of urinary TIMP-2 · IGFBP7 for acute kidney injury in adults: A PRISMA-compliant meta-analysis |pdf=|usr=}}{{28682920}} gab.com Text The diagnostic accuracy of urinary TIMP-2 · IGFBP7 for acute kidney injury in adults: A PRISMA-compliant meta-analysis JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=28682920 #FOAvip Introduction:: Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed this meta-analysis to assess the diagnostic accuracy of urinary [TIMP-2]·[IGFBP7] for AKI in adult patients. Methods:: We searched the PubMed, Embase, and Cochrane Library databases from database inception to March 2017. Two authors independently screened articles based on inclusion and exclusion criteria and assessed the methodological quality of each included study using the Quality Assessment of Diagnostic Accuracy Studies 2 criteria. Review Manager and STATA were used for all statistical analyses. Results:: Nine studies (n?=?1886) satisfied the inclusion criteria. Pooled analyses demonstrated that urinary [TIMP-2]·[IGFBP7] exhibited fair diagnostic accuracy for AKI (sensitivity [SEN] 0.83 [95% CI 0.75?0.89], specificity [SPE] 0.72 [95% CI 0.56?0.84], and area under the summary receiver operating characteristic [SROC] curve 0.86 [95% CI 0.82?0.88]) and AKI stage???2 (according to the 2012 Kidney Disease: Improving Global Outcomes [KDIGO] 2012 classification system; SEN 0.92 [95% CI 0.81?0.96], SPE 0.63 [95% CI 0.49?0.74], and area under the SROC curve 0.88 [95% CI 0.85?0.91]) in adult patients. Conclusion:: Our findings indicate that urinary [TIMP-2]·[IGFBP7] may be a reliable biomarker for the early detection of AKI. However, given the significant heterogeneity among the included studies, clinicians should be aware of the utility and limitations of this biomarker in clinical practice. Additional high-quality studies examining a larger sample of patients are required. Twit Text FOAVip The diagnostic accuracy of urinary TIMP-2 · IGFBP7 for acute kidney injury in adults: A PRISMA-compliant meta-analysis ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=28682920 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28682920 #FOAvip English Wikipedia <ref>{{Cite pmid|28682920}}</ref> The diagnostic accuracy of urinary TIMP-2 · IGFBP7 for acute kidney injury in adults: A PRISMA-compliant meta-analysis #MMPMID28682920 Liu C; Lu X; Mao Z; Kang H; Liu H; Pan L; Hu J; Wang L; Zhou F Medicine (Baltimore) 2017[Jul]; 96 (27): ä PMID28682920show ga Introduction:: Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed this meta-analysis to assess the diagnostic accuracy of urinary [TIMP-2]·[IGFBP7] for AKI in adult patients. Methods:: We searched the PubMed, Embase, and Cochrane Library databases from database inception to March 2017. Two authors independently screened articles based on inclusion and exclusion criteria and assessed the methodological quality of each included study using the Quality Assessment of Diagnostic Accuracy Studies 2 criteria. Review Manager and STATA were used for all statistical analyses. Results:: Nine studies (n?=?1886) satisfied the inclusion criteria. Pooled analyses demonstrated that urinary [TIMP-2]·[IGFBP7] exhibited fair diagnostic accuracy for AKI (sensitivity [SEN] 0.83 [95% CI 0.75?0.89], specificity [SPE] 0.72 [95% CI 0.56?0.84], and area under the summary receiver operating characteristic [SROC] curve 0.86 [95% CI 0.82?0.88]) and AKI stage???2 (according to the 2012 Kidney Disease: Improving Global Outcomes [KDIGO] 2012 classification system; SEN 0.92 [95% CI 0.81?0.96], SPE 0.63 [95% CI 0.49?0.74], and area under the SROC curve 0.88 [95% CI 0.85?0.91]) in adult patients. Conclusion:: Our findings indicate that urinary [TIMP-2]·[IGFBP7] may be a reliable biomarker for the early detection of AKI. However, given the significant heterogeneity among the included studies, clinicians should be aware of the utility and limitations of this biomarker in clinical practice. Additional high-quality studies examining a larger sample of patients are required. äThe diagnostic accuracy of urinary TIMP-2 · IGFBP7 for acute kidney (epmc).pdf DeepDyve Pubget Overpricing