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Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination #MMPMID28713859
Trivedi J; Lachapelle J; Vanderwolf KJ; Misra V; Willis CKR; Ratcliffe JM; Ness RW; Anderson JB; Kohn LM; James T; Stajich J; Fenton B
mSphere 2017[Jul]; 2 (4): ä PMID28713859show ga
Since its discovery in 2006, the emerging infectious disease known as white-nose syndrome has killed millions of bats in North America, making it one of the most devastating wildlife epidemics in recorded history. We demonstrate that there has been as yet only spontaneous mutation across the North American population of P. destructans, and we find no indication of recombination. Thus, selective forces, which might otherwise impact pathogenic virulence, have so far had essentially no genetic variation on which to act. Our study confirmed the time of origin for the first and, thus far, only introduction of P. destructans to North America. This system provides an unprecedented opportunity to follow the evolution of a host-pathogen interaction unfolding in real time.