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10.15252/embj.201696290 http://scihub22266oqcxt.onion/10.15252/embj.201696290 C5509998!5509998!28588064     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28588064&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28588064.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2017 ; 36 (14): 2146-60 Nephropedia Template TP {{tp|p=28588064|t=2017. Autotaxin?lysophosphatidic acid?LPA3 signaling at the embryo?epithelial boundary controls decidualization pathways |pdf=|usr=}}{{28588064}} gab.com Text Autotaxin lysophosphatidic acid LPA3 signaling at the embryo epithelial boundary controls decidualization pathways JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28588064 #FOAvip During pregnancy, up?regulation of heparin?binding (HB?) EGF and cyclooxygenase?2 (COX?2) in the uterine epithelium contributes to decidualization, a series of uterine morphological changes required for placental formation and fetal development. Here, we report a key role for the lipid mediator lysophosphatidic acid (LPA) in decidualization, acting through its G?protein?coupled receptor LPA3 in the uterine epithelium. Knockout of Lpar3 or inhibition of the LPA?producing enzyme autotaxin (ATX) in pregnant mice leads to HB?EGF and COX?2 down?regulation near embryos and attenuates decidual reactions. Conversely, selective pharmacological activation of LPA3 induces decidualization via up?regulation of HB?EGF and COX?2. ATX and its substrate lysophosphatidylcholine can be detected in the uterine epithelium and in pre?implantation?stage embryos, respectively. Our results indicate that ATX?LPA?LPA3 signaling at the embryo?epithelial boundary induces decidualization via the canonical HB?EGF and COX?2 pathways. Twit Text FOAVip Autotaxin lysophosphatidic acid LPA3 signaling at the embryo epithelial boundary controls decidualization pathways ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28588064 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28588064 #FOAvip English Wikipedia <ref>{{Cite pmid|28588064}}</ref> Autotaxin?lysophosphatidic acid?LPA3 signaling at the embryo?epithelial boundary controls decidualization pathways #MMPMID28588064 Aikawa S; Kano K; Inoue A; Wang J; Saigusa D; Nagamatsu T; Hirota Y; Fujii T; Tsuchiya S; Taketomi Y; Sugimoto Y; Murakami M; Arita M; Kurano M; Ikeda H; Yatomi Y; Chun J; Aoki J EMBO J 2017[Jul]; 36 (14): 2146-60 PMID28588064show ga During pregnancy, up?regulation of heparin?binding (HB?) EGF and cyclooxygenase?2 (COX?2) in the uterine epithelium contributes to decidualization, a series of uterine morphological changes required for placental formation and fetal development. Here, we report a key role for the lipid mediator lysophosphatidic acid (LPA) in decidualization, acting through its G?protein?coupled receptor LPA3 in the uterine epithelium. Knockout of Lpar3 or inhibition of the LPA?producing enzyme autotaxin (ATX) in pregnant mice leads to HB?EGF and COX?2 down?regulation near embryos and attenuates decidual reactions. Conversely, selective pharmacological activation of LPA3 induces decidualization via up?regulation of HB?EGF and COX?2. ATX and its substrate lysophosphatidylcholine can be detected in the uterine epithelium and in pre?implantation?stage embryos, respectively. Our results indicate that ATX?LPA?LPA3 signaling at the embryo?epithelial boundary induces decidualization via the canonical HB?EGF and COX?2 pathways. äAutotaxin?lysophosphatidic acid?LPA3 signaling at the embryo?epithelia(epmc).pdf DeepDyve Pubget Overpricing