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10.1182/blood-2016-02-698092

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suck abstract from ncbi


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pmid27458004      Blood 2016 ; 128 (9): 1226-33
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  • Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes #MMPMID27458004
  • Kortüm KM; Mai EK; Hanafiah NH; Shi CX; Zhu YX; Bruins L; Barrio S; Jedlowski P; Merz M; Xu J; Stewart RA; Andrulis M; Jauch A; Hillengass J; Goldschmidt H; Bergsagel PL; Braggio E; Stewart AK; Raab MS
  • Blood 2016[Sep]; 128 (9): 1226-33 PMID27458004show ga
  • The incidence of mutations within the MAPK pathway, the CRBN pathway, and TP53 is significantly increased in drug-refractory MM.Mutations in CRBN might contribute to IMiD resistance in drug-refractory MM.
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