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10.1038/s41467-017-00213-3 http://scihub22266oqcxt.onion/10.1038/s41467-017-00213-3 C5524634!5524634!28740109     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28740109.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (�): � Nephropedia Template TP {{tp|p=28740109|t=2017. Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation |pdf=|usr=}}{{28740109}} gab.com Text Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28740109 #FOAvip Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates inflammation during the development of colitis by modulating autophagy and mammalian target of rapamycin (mTOR)/NLRP3 pathway. Hypoxia significantly reduces tumor necrosis factor ?, interleukin (IL)-6 and NLRP3 expression, and increases the turnover of the autophagy protein p62 in colon biopsies of Crohn?s disease patients, and in samples from dextran sulfate sodium-treated mice and Il-10?/? mice. In vitro, NF-?B signaling and NLRP3 expression are reduced through hypoxia-induced autophagy. We also identify NLRP3 as a novel binding partner of mTOR. Dimethyloxalylglycine-mediated hydroxylase inhibition ameliorates colitis in mice, downregulates NLRP3 and promotes autophagy. We suggest that hypoxia counteracts inflammation through the downregulation of the binding of mTOR and NLRP3 and activation of autophagy. Twit Text FOAVip Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28740109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28740109 #FOAvip English Wikipedia <ref>{{Cite pmid|28740109}}</ref> Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation #MMPMID28740109 Cosin-Roger J; Simmen S; Melhem H; Atrott K; Frey-Wagner I; Hausmann M; de Valli�re C; Spalinger MR; Spielmann P; Wenger RH; Zeitz J; Vavricka SR; Rogler G; Ruiz PA Nat Commun 2017[]; 8 (�): � PMID28740109show ga Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates inflammation during the development of colitis by modulating autophagy and mammalian target of rapamycin (mTOR)/NLRP3 pathway. Hypoxia significantly reduces tumor necrosis factor ?, interleukin (IL)-6 and NLRP3 expression, and increases the turnover of the autophagy protein p62 in colon biopsies of Crohn?s disease patients, and in samples from dextran sulfate sodium-treated mice and Il-10?/? mice. In vitro, NF-?B signaling and NLRP3 expression are reduced through hypoxia-induced autophagy. We also identify NLRP3 as a novel binding partner of mTOR. Dimethyloxalylglycine-mediated hydroxylase inhibition ameliorates colitis in mice, downregulates NLRP3 and promotes autophagy. We suggest that hypoxia counteracts inflammation through the downregulation of the binding of mTOR and NLRP3 and activation of autophagy. �Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downreg(epmc).pdf DeepDyve Pubget Overpricing