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10.1158/1078-0432.CCR-15-1447 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-15-1447 C5536176!5536176!26459179     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26459179&cmd=llinks): Failed to open stream: HTTP request failed! 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Inactivation of Hippo pathway is significantly associated with poor prognosis in hepatocellular carcinoma |pdf=|usr=}}{{26459179}} gab.com Text Inactivation of Hippo pathway is significantly associated with poor prognosis in hepatocellular carcinoma JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26459179 #FOAvip Purpose: The Hippo pathway is a tumor suppressor in the liver. However, the clinical significance of Hippo pathway inactivation in HCC is not clearly defined. We analyzed genomic data from human and mouse tissues to determine clinical relevance of Hippo pathway inactivation in HCC. Experimental Design: We analyzed gene expression data from Mst1/2?/? and Sav1?/? mice and identified a 610-gene expression signature reflecting Hippo pathway inactivation in the liver (silence of Hippo [SOH] signature). By integrating gene expression data from mouse models with those from human HCC tissues, we developed a prediction model that could identify HCC patients with an inactivated Hippo pathway and used it to test its significance in HCC patients, via univariate and multivariate Cox analyses. Results: HCC patients (National Cancer Institute cohort, n = 113) with the SOH signature had a significantly poorer prognosis than those without the SOH signature (P < 0.001 for overall survival [OS]). The significant association of the signature with poor prognosis was further validated in the Korean (n=100, P = 0.006 for OS) and Fudan University cohorts (n=242, P = 0.001 for OS). On multivariate analysis, the signature was an independent predictor of recurrence-free survival (hazard ratio, 1.6; 95% confidence interval, 1.12?2.28: P = 0.008). We also demonstrated significant concordance between the SOH HCC subtype and the hepatic stem cell HCC subtype that had been identified in a previous study (P < 0.001). Conclusions: Inactivation of the Hippo pathway in HCC is significantly associated with poor prognosis. Twit Text FOAVip Inactivation of Hippo pathway is significantly associated with poor prognosis in hepatocellular carcinoma ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26459179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26459179 #FOAvip English Wikipedia <ref>{{Cite pmid|26459179}}</ref> Inactivation of Hippo pathway is significantly associated with poor prognosis in hepatocellular carcinoma #MMPMID26459179 Sohn BH; Shim JJ; Kim SB; Jang KY; Kim SM; Kim JH; Hwang JE; Jang HJ; Lee HS; Kim SC; Jeong W; Kim SS; Park ES; Heo J; Kim YJ; Kim DG; Leem SH; Kaseb A; Hassan MM; Cha M; Chu IS; Johnson RL; Park YY; Lee JS Clin Cancer Res 2016[Mar]; 22 (5): 1256-64 PMID26459179show ga Purpose: The Hippo pathway is a tumor suppressor in the liver. However, the clinical significance of Hippo pathway inactivation in HCC is not clearly defined. We analyzed genomic data from human and mouse tissues to determine clinical relevance of Hippo pathway inactivation in HCC. Experimental Design: We analyzed gene expression data from Mst1/2?/? and Sav1?/? mice and identified a 610-gene expression signature reflecting Hippo pathway inactivation in the liver (silence of Hippo [SOH] signature). By integrating gene expression data from mouse models with those from human HCC tissues, we developed a prediction model that could identify HCC patients with an inactivated Hippo pathway and used it to test its significance in HCC patients, via univariate and multivariate Cox analyses. Results: HCC patients (National Cancer Institute cohort, n = 113) with the SOH signature had a significantly poorer prognosis than those without the SOH signature (P < 0.001 for overall survival [OS]). The significant association of the signature with poor prognosis was further validated in the Korean (n=100, P = 0.006 for OS) and Fudan University cohorts (n=242, P = 0.001 for OS). On multivariate analysis, the signature was an independent predictor of recurrence-free survival (hazard ratio, 1.6; 95% confidence interval, 1.12?2.28: P = 0.008). We also demonstrated significant concordance between the SOH HCC subtype and the hepatic stem cell HCC subtype that had been identified in a previous study (P < 0.001). Conclusions: Inactivation of the Hippo pathway in HCC is significantly associated with poor prognosis. äInactivation of Hippo pathway is significantly associated with poor pr(epmc).pdf DeepDyve Pubget Overpricing