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Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling #MMPMID28857084
Kim JC; Jung YS; Lee HY; Park JS; Bae YS
Exp Mol Med 2017[Aug]; 49 (8): e369- PMID28857084show ga
In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBP?, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.