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10.1111/imm.12766 http://scihub22266oqcxt.onion/10.1111/imm.12766 C5588763!5588763!28556921     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28556921.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunology 2017 ; 152 (2): 265-75 Nephropedia Template TP {{tp|p=28556921|t=2017. Membrane?bound Dickkopf?1 in Foxp3+ regulatory T cells suppresses T?cell?mediated autoimmune colitis |pdf=|usr=}}{{28556921}} gab.com Text Membrane bound Dickkopf 1 in Foxp3+ regulatory T cells suppresses T cell mediated autoimmune colitis JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28556921 #FOAvip Induction of tolerance is a key mechanism to maintain or to restore immunological homeostasis. Here we show that Foxp3+ regulatory T (Treg) cells use Dickkopf?1 (DKK?1) to regulate T?cell?mediated tolerance in the T?cell?mediated autoimmune colitis model. Treg cells from DKK?1 hypomorphic doubleridge mice failed to control CD4+ T?cell proliferation, resulting in CD4 T?cell?mediated autoimmune colitis. Thymus?derived Treg cells showed a robust expression of DKK?1 but not in naive or effector CD4 T cells. DKK?1 expression in Foxp3+ Treg cells was further increased upon T?cell receptor stimulation in vitro and in vivo. Interestingly, Foxp3+ Treg cells expressed DKK?1 in the cell membrane and the functional inhibition of DKK?1 using DKK?1 monoclonal antibody abrogated the suppressor function of Foxp3+ Treg cells. DKK?1 expression was dependent on de novo protein synthesis and regulated by the mitogen?activated protein kinase pathway but not by the canonical Wnt pathway. Taken together, our results highlight membrane?bound DKK?1 as a novel Treg?derived mediator to maintain immunological tolerance in T?cell?mediated autoimmune colitis. Twit Text FOAVip Membrane bound Dickkopf 1 in Foxp3+ regulatory T cells suppresses T cell mediated autoimmune colitis ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=28556921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28556921 #FOAvip English Wikipedia <ref>{{Cite pmid|28556921}}</ref> Membrane?bound Dickkopf?1 in Foxp3+ regulatory T cells suppresses T?cell?mediated autoimmune colitis #MMPMID28556921 Chae W; Park J; Henegariu O; Yilmaz S; Hao L; Bothwell ALM Immunology 2017[Oct]; 152 (2): 265-75 PMID28556921show ga Induction of tolerance is a key mechanism to maintain or to restore immunological homeostasis. Here we show that Foxp3+ regulatory T (Treg) cells use Dickkopf?1 (DKK?1) to regulate T?cell?mediated tolerance in the T?cell?mediated autoimmune colitis model. Treg cells from DKK?1 hypomorphic doubleridge mice failed to control CD4+ T?cell proliferation, resulting in CD4 T?cell?mediated autoimmune colitis. Thymus?derived Treg cells showed a robust expression of DKK?1 but not in naive or effector CD4 T cells. DKK?1 expression in Foxp3+ Treg cells was further increased upon T?cell receptor stimulation in vitro and in vivo. Interestingly, Foxp3+ Treg cells expressed DKK?1 in the cell membrane and the functional inhibition of DKK?1 using DKK?1 monoclonal antibody abrogated the suppressor function of Foxp3+ Treg cells. DKK?1 expression was dependent on de novo protein synthesis and regulated by the mitogen?activated protein kinase pathway but not by the canonical Wnt pathway. Taken together, our results highlight membrane?bound DKK?1 as a novel Treg?derived mediator to maintain immunological tolerance in T?cell?mediated autoimmune colitis. äMembrane?bound Dickkopf?1 in Foxp3+ regulatory T cells suppresses T?ce(epmc).pdf DeepDyve Pubget Overpricing