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10.18632/oncotarget.19646 http://scihub22266oqcxt.onion/10.18632/oncotarget.19646 C5593527!5593527!28915556     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28915556.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (34): 55837-47 Nephropedia Template TP {{tp|p=28915556|t=2017. Critical roles of SMYD2-mediated ?-catenin methylation for nuclear translocation and activation of Wnt signaling |pdf=|usr=}}{{28915556}} gab.com Text Critical roles of SMYD2-mediated -catenin methylation for nuclear translocation and activation of Wnt signaling JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915556 #FOAvip Accumulation of ?-catenin in the nucleus is a hallmark of activation of the Wnt/?-catenin signaling pathway, which drives development of a large proportion of human cancers. However, the mechanism of ?-catenin nuclear translocation has not been well investigated. Here we report biological significance of SMYD2-mediated lysine 133 (K133) methylation of ?-catenin on its nuclear translocation. Knockdown of SMYD2 attenuates the nuclear localization of ?-catenin protein in human cancer cells. Consequently, transcriptional levels of well-known Wnt-signaling molecules, cMYC and CCND1, are significantly reduced. Substitution of lysine 133 to alanine in ?-catenin almost completely abolishes its nuclear localization. We also demonstrate the K133 methylation is critical for the interaction of ?-catenin with FOXM1. Furthermore, after treatment with a SMYD2 inhibitor, significant reduction of nuclear ?-catenin and subsequent induction of cancer cell death are observed. Accordingly, our results imply that ?-catenin methylation by SMYD2 promotes its nuclear translocation and activation of Wnt signaling. Twit Text FOAVip Critical roles of SMYD2-mediated -catenin methylation for nuclear translocation and activation of Wnt signaling ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28915556 #FOAvip English Wikipedia <ref>{{Cite pmid|28915556}}</ref> Critical roles of SMYD2-mediated ?-catenin methylation for nuclear translocation and activation of Wnt signaling #MMPMID28915556 Deng X; Hamamoto R; Vougiouklakis T; Wang R; Yoshioka Y; Suzuki T; Dohmae N; Matsuo Y; Park JH; Nakamura Y Oncotarget 2017[Aug]; 8 (34): 55837-47 PMID28915556show ga Accumulation of ?-catenin in the nucleus is a hallmark of activation of the Wnt/?-catenin signaling pathway, which drives development of a large proportion of human cancers. However, the mechanism of ?-catenin nuclear translocation has not been well investigated. Here we report biological significance of SMYD2-mediated lysine 133 (K133) methylation of ?-catenin on its nuclear translocation. Knockdown of SMYD2 attenuates the nuclear localization of ?-catenin protein in human cancer cells. Consequently, transcriptional levels of well-known Wnt-signaling molecules, cMYC and CCND1, are significantly reduced. Substitution of lysine 133 to alanine in ?-catenin almost completely abolishes its nuclear localization. We also demonstrate the K133 methylation is critical for the interaction of ?-catenin with FOXM1. Furthermore, after treatment with a SMYD2 inhibitor, significant reduction of nuclear ?-catenin and subsequent induction of cancer cell death are observed. Accordingly, our results imply that ?-catenin methylation by SMYD2 promotes its nuclear translocation and activation of Wnt signaling. äCritical roles of SMYD2-mediated ?-catenin methylation for nuclear tra(epmc).pdf DeepDyve Pubget Overpricing