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10.1038/s41598-017-11634-x http://scihub22266oqcxt.onion/10.1038/s41598-017-11634-x C5593901!5593901!28894284     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28894284&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28894284.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28894284|t=2017. TREM2 promotes A? phagocytosis by upregulating C/EBP?-dependent CD36 expression in microglia |pdf=|usr=}}{{28894284}} gab.com Text TREM2 promotes A phagocytosis by upregulating C/EBP -dependent CD36 expression in microglia JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894284 #FOAvip TREM2 plays a critical role in the alleviation of Alzheimer?s disease by promoting A? phagocytosis by microglia, but the detailed molecular mechanism underlying TREM2-induced direct phagocytic activity of A? remains to be revealed. We found that learning and memory functions were improved in aged TREM2 TG mice, with the opposite effects in KO mice. The amount of phagocytosed A? was significantly reduced in the primary microglia of KO mice. CD36 expression in primary microglia was greater in TG than in WT mice but was substantially decreased in KO mice. The expression of C/EBP?, an upstream transcriptional activator of CD36, was also elevated in primary microglia of TG mice but decreased in KO mice. The transcription of CD36 was markedly increased by TREM2 overexpression, and this effect was suppressed by a mutation of the C/EBP? binding site on the CD36 promoter. The TREM2-induced expression of CD36 and C/EBP? was inhibited by treatment with PI3K/AKT signaling blockers, and phosphorylation of AKT was elevated in TREM2-overexpressing BV2 cells. The present study provides evidence that TREM2 is required for preventing loss of memory and learning in Alzheimer?s disease by regulating C/EBP?-dependent CD36 expression and the consequent A? phagocytosis. Twit Text FOAVip TREM2 promotes A phagocytosis by upregulating C/EBP -dependent CD36 expression in microglia ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894284 #FOAvip English Wikipedia <ref>{{Cite pmid|28894284}}</ref> TREM2 promotes A? phagocytosis by upregulating C/EBP?-dependent CD36 expression in microglia #MMPMID28894284 Kim SM; Mun BR; Lee SJ; Joh Y; Lee HY; Ji KY; Choi HR; Lee EH; Kim EM; Jang JH; Song HW; Mook-Jung I; Choi WS; Kang HS Sci Rep 2017[]; 7 (ä): ä PMID28894284show ga TREM2 plays a critical role in the alleviation of Alzheimer?s disease by promoting A? phagocytosis by microglia, but the detailed molecular mechanism underlying TREM2-induced direct phagocytic activity of A? remains to be revealed. We found that learning and memory functions were improved in aged TREM2 TG mice, with the opposite effects in KO mice. The amount of phagocytosed A? was significantly reduced in the primary microglia of KO mice. CD36 expression in primary microglia was greater in TG than in WT mice but was substantially decreased in KO mice. The expression of C/EBP?, an upstream transcriptional activator of CD36, was also elevated in primary microglia of TG mice but decreased in KO mice. The transcription of CD36 was markedly increased by TREM2 overexpression, and this effect was suppressed by a mutation of the C/EBP? binding site on the CD36 promoter. The TREM2-induced expression of CD36 and C/EBP? was inhibited by treatment with PI3K/AKT signaling blockers, and phosphorylation of AKT was elevated in TREM2-overexpressing BV2 cells. The present study provides evidence that TREM2 is required for preventing loss of memory and learning in Alzheimer?s disease by regulating C/EBP?-dependent CD36 expression and the consequent A? phagocytosis. äTREM2 promotes A? phagocytosis by upregulating C/EBP?-dependent CD36 e(epmc).pdf DeepDyve Pubget Overpricing