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10.1038/cddis.2017.389 http://scihub22266oqcxt.onion/10.1038/cddis.2017.389 C5596575!5596575!28817116     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28817116&cmd=llinks): Failed to open stream: HTTP request failed! 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Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway |pdf=|usr=}}{{28817116}} gab.com Text Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28817116 #FOAvip Tanshinones belong to a group of lipophilic constituents of Salvia miltiorrhiza Bunge (Danshen), which is widely used in traditional Chinese medicine. A deluge of studies demonstrated that tanshinones exert anti-inflammatory effects, but the underlying mechanisms remain unclear to date. This study investigated the anti-inflammatory effects and mechanisms of total tanshinones (TTN). TTN suppressed the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the secretion of TNF-?, IL-6, and IL-1? in RAW264.7 cells, bone marrow-derived macrophages, and THP-1 cells. TTN attenuated the LPS-induced transcriptional activity of NF-?B and decreased I?B-? and IKK phosphorylation and NF-?B/p65 nuclear translocation. Furthermore, TTN inhibited the LPS-induced transcriptional activity of AP-1, which was induced by the reduction of JNK1/2, ERK1/2, and p38MAPK phosphorylation. TTN blocked LPS-induced Toll-like receptor 4 (TLR4) dimerization, which consequently decreased MyD88 recruitment and TAK1 phosphorylation. In addition, TTN pretreatment effectively inhibited xylene-induced ear edema and LPS-induced septic death and improved LPS-induced acute kidney injury in mice. TTN exerts anti-inflammatory effects in vitro and in vivo by blocking TLR4 dimerization to activate MyD88?TAK1?NF-?B/MAPK signaling cascades, which provide the molecular basis of the anti-inflammatory effect of Danshen and suggest that TTN is a potential agent for the treatment of inflammatory diseases. Twit Text FOAVip Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28817116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28817116 #FOAvip English Wikipedia <ref>{{Cite pmid|28817116}}</ref> Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway #MMPMID28817116 Gao H; Liu X; Sun W; Kang N; Liu Y; Yang S; Xu Qm; Wang C; Chen X Cell Death Dis 2017[Aug]; 8 (8): e3004- PMID28817116show ga Tanshinones belong to a group of lipophilic constituents of Salvia miltiorrhiza Bunge (Danshen), which is widely used in traditional Chinese medicine. A deluge of studies demonstrated that tanshinones exert anti-inflammatory effects, but the underlying mechanisms remain unclear to date. This study investigated the anti-inflammatory effects and mechanisms of total tanshinones (TTN). TTN suppressed the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the secretion of TNF-?, IL-6, and IL-1? in RAW264.7 cells, bone marrow-derived macrophages, and THP-1 cells. TTN attenuated the LPS-induced transcriptional activity of NF-?B and decreased I?B-? and IKK phosphorylation and NF-?B/p65 nuclear translocation. Furthermore, TTN inhibited the LPS-induced transcriptional activity of AP-1, which was induced by the reduction of JNK1/2, ERK1/2, and p38MAPK phosphorylation. TTN blocked LPS-induced Toll-like receptor 4 (TLR4) dimerization, which consequently decreased MyD88 recruitment and TAK1 phosphorylation. In addition, TTN pretreatment effectively inhibited xylene-induced ear edema and LPS-induced septic death and improved LPS-induced acute kidney injury in mice. TTN exerts anti-inflammatory effects in vitro and in vivo by blocking TLR4 dimerization to activate MyD88?TAK1?NF-?B/MAPK signaling cascades, which provide the molecular basis of the anti-inflammatory effect of Danshen and suggest that TTN is a potential agent for the treatment of inflammatory diseases. äTotal tanshinones exhibits anti-inflammatory effects through blocking (epmc).pdf DeepDyve Pubget Overpricing